1 667

Cited 4 times in

Sexual precocity in hypomelanosis of Ito: mosaicism-associated case report and literature review

DC Field Value Language
dc.contributor.author김덕희-
dc.contributor.author이민걸-
dc.contributor.author채현욱-
dc.date.accessioned2014-12-20T16:38:40Z-
dc.date.available2014-12-20T16:38:40Z-
dc.date.issued2011-
dc.identifier.issn0011-9059-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93105-
dc.description.abstractBACKGROUND: Hypomelanosis of Ito (HI), a neurocutaneous disorder characterized by hypopigmented skin lesions along Blaschko's line with multiple accompanying diseases, may occasionally present with sexual precocity. METHODS: We reviewed cases of HI with sexual precocity reported in the literature and focused on collecting information on other associated organ abnormalities, chromosomal karyotype, and type of sexual precocity. We also present our own case report. RESULTS: Five children with sexual precocity in HI were studied. All patients were full-term females without significant family history. Their ages ranged from three years to 11 years. Skin lesions involved the trunk and limbs. Developmental delay was present in all patients. Central nervous system involvement was found in four patients. Craniofacial abnormalities were present in four patients. Eye involvement was present in two patients. Limb abnormalities (brachydactyly and clinodactyly) were present in two patients. Skeletal organ involvement was present in three patients. Other skin lesions were present in three patients. Dental abnormalities occurred in one patient. Of the five patients, four demonstrated a peripheral type of sexual precocity, and one presented with central type sexual precocity. Vaginal bleeding was present in two patients. Chromosomal karyotype abnormalities were found in two patients, and mosaicism was present in one of these. CONCLUSIONS: Hypomelanosis of Ito is a syndrome characterized by cutaneous signs frequently associated with nervous, ocular, and musculoskeletal system abnormalities. Although it is rarely reported in conjunction with HI, physicians should recognize sexual precocity as a possible associated symptom.-
dc.description.statementOfResponsibilityopen-
dc.format.extent168~174-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbnormalities, Multiple/diagnostic imaging-
dc.subject.MESHAbnormalities, Multiple/genetics-
dc.subject.MESHAbnormalities, Multiple/pathology-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHChromosome Aberrations-
dc.subject.MESHDevelopmental Disabilities/genetics*-
dc.subject.MESHDevelopmental Disabilities/pathology-
dc.subject.MESHExtremities-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaryotyping-
dc.subject.MESHMosaicism*-
dc.subject.MESHNeurocutaneous Syndromes/genetics-
dc.subject.MESHPigmentation Disorders/genetics*-
dc.subject.MESHPigmentation Disorders/pathology-
dc.subject.MESHPuberty, Precocious/genetics-
dc.subject.MESHPuberty, Precocious/pathology-
dc.subject.MESHRadiography-
dc.subject.MESHRetrospective Studies-
dc.titleSexual precocity in hypomelanosis of Ito: mosaicism-associated case report and literature review-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJin Mo Park-
dc.contributor.googleauthorHee Jung Kim-
dc.contributor.googleauthorTaegyun Kim-
dc.contributor.googleauthorHyun Wook Chae-
dc.contributor.googleauthorDuk Hee Kim-
dc.contributor.googleauthorMin-Geol Lee-
dc.identifier.doi10.1111/j.1365-4632.2010.04639.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00378-
dc.contributor.localIdA02779-
dc.contributor.localIdA04026-
dc.relation.journalcodeJ01105-
dc.identifier.eissn1365-4632-
dc.identifier.pmid21244380-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2010.04639.x/abstract-
dc.contributor.alternativeNameKim, Duk Hee-
dc.contributor.alternativeNameLee, Min Geol-
dc.contributor.alternativeNameChae, Hyun Wook-
dc.contributor.affiliatedAuthorKim, Duk Hee-
dc.contributor.affiliatedAuthorLee, Min Geol-
dc.contributor.affiliatedAuthorChae, Hyun Wook-
dc.rights.accessRightsnot free-
dc.citation.volume50-
dc.citation.number2-
dc.citation.startPage168-
dc.citation.endPage174-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF DERMATOLOGY, Vol.50(2) : 168-174, 2011-
dc.identifier.rimsid28028-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.