Cited 17 times in
G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.
DC Field | Value | Language |
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dc.contributor.author | 권혁문 | - |
dc.date.accessioned | 2014-12-20T16:38:06Z | - |
dc.date.available | 2014-12-20T16:38:06Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1079-5642 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93087 | - |
dc.description.abstract | OBJECTIVE: Gα(12/13) play a role in oncogenic transformation and tumor growth. Cysteine-rich protein 61 (CYR61) is a growth-factor-inducible angiogenic factor. In view of potential overlapping functions between Gα(12/13) and CYR61, this study investigated the role of these G proteins in CYR61 induction in association with hyperplastic vascular abnormality. METHODS AND RESULTS: Overexpression of activated Gα(12) or Gα(13) induced CYR61 expression in vascular smooth muscle cells (VSMCs). Gene knockdown and knockout experiments revealed that sphingosine-1-phosphate (S1P) treatment induced CYR61 via Gα(12/13). JunD/activator protein-1 (AP-1) was identified as a transcription factor required for CYR61 transactivation by S1P. Deficiencies in Gα(12/13) abrogated AP-1 activation and AP-1-mediated CYR61 induction. c-Jun N-terminal kinase was responsible for CYR61 induction. Moreover, deficiencies of Gα(12/13) abolished c-Jun N-terminal kinase-dependent CYR61 induction by S1P. N-acetyl-l-cysteine or NADPH oxidase inhibitor treatment reversed CYR61 induction by S1P, indicating that reactive oxygen species are responsible for this process. The levels of Gα(12/13) were increased within thickened intimas and medias in wire-injured mouse femoral arteries, which was accompanied by simultaneous CYR61 induction. Moreover, Gα(12/13) and CYR61 were costained in the arteriosclerotic lesions immediately adjacent to human tumor tissues. CONCLUSIONS: Gα(12/13) regulate AP-1-dependent CYR61 induction in VSMCs and promote VSMC migration, and they are upregulated with CYR61 in arteriosclerotic lesions. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 861~869 | - |
dc.relation.isPartOf | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young Mi Kim | - |
dc.contributor.googleauthor | Sung-Chul Lim | - |
dc.contributor.googleauthor | Chang Yeob Han | - |
dc.contributor.googleauthor | Hee Yeon Kay | - |
dc.contributor.googleauthor | Il Je Cho | - |
dc.contributor.googleauthor | Sung Hwan Ki | - |
dc.contributor.googleauthor | Moo Yeol Lee | - |
dc.contributor.googleauthor | Hyuck Moon Kwon | - |
dc.contributor.googleauthor | Chang Ho Lee | - |
dc.contributor.googleauthor | Sang Geon Kim | - |
dc.identifier.doi | 10.1161/ATVBAHA.110.218552 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00260 | - |
dc.relation.journalcode | J00238 | - |
dc.identifier.eissn | 1524-4636 | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | G proteins | - |
dc.subject.keyword | oncogenes | - |
dc.subject.keyword | signal transduction | - |
dc.subject.keyword | vascular biology | - |
dc.subject.keyword | G 12/13 | - |
dc.subject.keyword | cysteine-rich protein 61 | - |
dc.subject.keyword | sphingosine-1-phosphate | - |
dc.subject.keyword | vascular smooth muscle cell | - |
dc.contributor.alternativeName | Kwon, Hyuck Moon | - |
dc.contributor.affiliatedAuthor | Kwon, Hyuck Moon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 861 | - |
dc.citation.endPage | 869 | - |
dc.identifier.bibliographicCitation | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.31(4) : 861-869, 2011 | - |
dc.identifier.rimsid | 28019 | - |
dc.type.rims | ART | - |
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