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Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification

DC Field Value Language
dc.contributor.author김형준-
dc.contributor.author차인호-
dc.date.accessioned2014-12-20T16:37:52Z-
dc.date.available2014-12-20T16:37:52Z-
dc.date.issued2011-
dc.identifier.issn1079-2104-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93080-
dc.description.abstractBACKGROUND: Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, has been shown to occur via a multistep process driven by the accumulation of carcinogen-induced genetic changes. STUDY DESIGN: Array-based comparative genomic hybridization (aCGH) and multiplex ligation-dependent probe amplification (MLPA) were conducted to screen human genomewide alterations on fresh tissues of the cancer area, the dysplastic transitional area, and the resection margin (normal) free of tumor; these samples were obtained from 7 OSCC patients. RESULTS: The highest amplification frequencies (100%, 7/7) were detected in FAM5B, TIPARP, PIK3CA, NLGN1, FGF10, HDAC9, GRM3, DDEF1, EDNRB, CHRDL1, and HTR2C, and the highest deletion frequencies in THRAP3, CTTNBP2NL, GATAD2B, REL, CKAP2L, RHOA, EIF4E3, PDLIM5, FBXO3, NEUROD4, and ABCA5 in the OSCC. In the dysplasia, amplification (100%, 7/7) was detected in RNF36 and deletion in CKAP2L and TCF8. We could detect large differences with MLPA in the number of alterations between the cancer or dysplasia versus the normal area with P values of <.001. CONCLUSION: These findings indicate that these DNA copy number changes on each chromosome in the 3 categories may be associated with OSCC tumorigenesis and/or progression.-
dc.description.statementOfResponsibilityopen-
dc.format.extent594~607-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Squamous Cell/genetics*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHChromosome Aberrations-
dc.subject.MESHCluster Analysis-
dc.subject.MESHComparative Genomic Hybridization*-
dc.subject.MESHDNA Copy Number Variations*-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMouth Mucosa/pathology-
dc.subject.MESHMouth Neoplasms/genetics*-
dc.subject.MESHMouth Neoplasms/pathology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNucleic Acid Amplification Techniques*-
dc.subject.MESHOligonucleotide Array Sequence Analysis/methods-
dc.titleGenetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral and Maxillofacial Surgery (구강악안면외과학)-
dc.contributor.googleauthorJeong-Dan Cha-
dc.contributor.googleauthorHyung Jun Kim-
dc.contributor.googleauthorIn-Ho Cha-
dc.identifier.doi10.1016/j.tripleo.2010.11.020-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04002-
dc.relation.journalcodeJ02443-
dc.identifier.eissn1528-395X-
dc.identifier.pmid21334929-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1079210410009200-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.rights.accessRightsnot free-
dc.citation.volume111-
dc.citation.number5-
dc.citation.startPage594-
dc.citation.endPage607-
dc.identifier.bibliographicCitationORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, Vol.111(5) : 594-607, 2011-
dc.identifier.rimsid28015-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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