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Tuberculous encephalopathy without meningitis: Pathology and brain MRI findings

Authors
 Kim H.-J.  ;  Shim K.-W.  ;  Kim T.-S.  ;  Park S.  ;  Kim E.-Y.  ;  Kim S.-H.  ;  Park M.-S.  ;  Lee M.-K. 
Citation
 European Neurology, Vol.65(3) : 156-159, 2011 
Journal Title
 European Neurology 
ISSN
 0014-3022 
Issue Date
2011
Abstract
Tuberculous encephalopathy (TBE) is an established disease entity of diffuse cerebral damage occurring with tuberculosis and an underlying immune pathogenesis. However, the presence of this disease entity remains controversial. We report a 15-year-old boy with seizures and a progressive decline of cognitive function. Brain MRI showed diffuse, hyperintense lesions in the white matter on a T2-weighted image, with gadolinium enhancement on a T1-weighted image. Brain biopsy revealed demyelination and granuloma in the white matter. Ziehl-Neelsen staining showed acid-fast bacilli in the granulomas. Antituberculous medication with concomitant steroid treatment resulted in radiological resolution in addition to clinical improvement. Clinicopathological evidence in this case provides additional convincing evidence of TBE as a disease entity distinct from tuberculous meningitis.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93076
DOI
10.1159/000324170
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김세훈(Kim, Se Hoon) ; 김응엽(Kim, Eung Yeop) ; 김태승(Kim, Tai Seung) ; 박무석(Park, Moo Suk) ; 박수철(Park, Soo Chul) ; 심규원(Shim, Kyu Won) ; 이문규(Lee, Moon Kyu)
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http://www.karger.com/Article/FullText/324170
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