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Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model

DC Field Value Language
dc.contributor.author방동식-
dc.date.accessioned2014-12-20T16:35:29Z-
dc.date.available2014-12-20T16:35:29Z-
dc.date.issued2011-
dc.identifier.issn0014-2999-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93005-
dc.description.abstractSynthesized pyridine compound derivatives (SK94, SK126) from a natural lead source were administered to mice to test for possible anti-TNF alpha and anti-inflammatory activities. Lipopolysaccharide (LPS)-induced TNF alpha production was analyzed in the endothelial cells, Raw 264.7 cells, and serum of normal mice after treatment with SK compounds. These compounds were also orally administered to a herpes simplex virus (HSV)-induced Behcet's disease mouse model to investigate their anti-inflammatory therapeutic effect. TNF alpha production was inhibited in a dose-dependent manner in the SK94 treated cells. E-selectin, VCAM-1, and ICAM-1 mRNA levels were also down-regulated. Treatment with 30mg/kg SK94 inhibited 55% of the TNF alpha production in LPS challenged Balb/c mice (n=8). SK94 and SK126 were administered to the Behcet's disease-like mice for five consecutive days and SK94 improved in five out of six mice (83%), while it only improved in one out of nine mice (11%) in the pH 1.2 saline (artificial gastric juice) group (P<0.005), four out of ten mice (40%) in the thalidomide group (P<0.05), and six out of seven (86%) in the SK126 group (P<0.005). Soluble ICAM-1 was inhibited by 23.8% in the sera of SK94 treated mice and by 34.6% in SK126 treated mice when compared to artificial gastric juice. Based on these findings, SK compounds could be candidates for clinical trials.-
dc.description.statementOfResponsibilityopen-
dc.format.extent167~172-
dc.relation.isPartOfEUROPEAN JOURNAL OF PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAnimals-
dc.subject.MESHBehcet Syndrome/drug therapy-
dc.subject.MESHBehcet Syndrome/genetics-
dc.subject.MESHBehcet Syndrome/metabolism*-
dc.subject.MESHBehcet Syndrome/virology*-
dc.subject.MESHCell Adhesion Molecules/genetics-
dc.subject.MESHCell Adhesion Molecules/metabolism*-
dc.subject.MESHCell Line-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDown-Regulation/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMolecular Weight-
dc.subject.MESHNaphthyridines/administration & dosage-
dc.subject.MESHNaphthyridines/chemical synthesis-
dc.subject.MESHNaphthyridines/chemistry-
dc.subject.MESHNaphthyridines/pharmacology-
dc.subject.MESHPyridines/administration & dosage-
dc.subject.MESHPyridines/chemical synthesis-
dc.subject.MESHPyridines/chemistry*-
dc.subject.MESHPyridines/pharmacology*-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHSimplexvirus/physiology*-
dc.subject.MESHTumor Necrosis Factor-alpha/antagonists & inhibitors-
dc.subject.MESHTumor Necrosis Factor-alpha/biosynthesis-
dc.subject.MESHTumor Necrosis Factor-alpha/metabolism*-
dc.titleSynthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorBunsoon Choi-
dc.contributor.googleauthorJoohyon Kim-
dc.contributor.googleauthorEun-So Lee-
dc.contributor.googleauthorDongsik Bang-
dc.contributor.googleauthorSeonghyang Sohn-
dc.identifier.doi10.1016/j.ejphar.2011.01.062-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01784-
dc.relation.journalcodeJ00842-
dc.identifier.eissn1879-0712-
dc.identifier.pmid21315710-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0014299911001208-
dc.subject.keywordPyridine compound derivative-
dc.subject.keywordBehcet's disease-
dc.subject.keywordHerpes simplex virus-
dc.subject.keywordTNF alpha-
dc.subject.keywordOral administration-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordMouse model-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.rights.accessRightsnot free-
dc.citation.volume657-
dc.citation.number1-3-
dc.citation.startPage167-
dc.citation.endPage172-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF PHARMACOLOGY, Vol.657(1-3) : 167-172, 2011-
dc.identifier.rimsid27965-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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