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Insulin-like growth factor II mRNA-binding protein 3: a novel prognostic biomarker for oral squamous cell carcinoma

Authors
 Shengjin Li  ;  JeongDan Cha  ;  Jin Kim  ;  Ki-Yeol Kim  ;  Hyung-Jun Kim  ;  Woong Nam  ;  In-Ho Cha 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.33(3) : 368-374, 2011 
Journal Title
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
ISSN
 1043-3074 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biomarkers, Tumor/blood* ; Biopsy, Needle ; Blotting, Western ; Carcinoma, Squamous Cell/blood* ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/mortality ; Chi-Square Distribution ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Insulin-Like Growth Factor Binding Protein 3/blood* ; Insulin-Like Growth Factor II/metabolism* ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mouth Neoplasms/blood* ; Mouth Neoplasms/genetics ; Mouth Neoplasms/mortality ; Multivariate Analysis ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; RNA, Messenger/analysis ; Retrospective Studies ; Sensitivity and Specificity ; Statistics, Nonparametric ; Survival Rate
Abstract
BACKGROUND: Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3 can be used as a prognostic biomarker for OSCC.

METHODS: We performed immunohistochemistry and Western blotting to examine IMP3 expression in human tissues. We also investigated correlations among IMP3 expression, clinicopathologic factors, and overall survival.

RESULTS: IMP3 was overexpressed in OSCC cells. The expression was correlated with high histologic grade, lymph node metastasis, and advanced tumor and clinical stages. Univariate analysis indicated that advanced clinical stages, lymph node metastases, and IMP3 expression were predictive factors for OSCC. Multivariate analysis showed that IMP3 expression was an independent prognostic indicator for OSCC.

CONCLUSIONS: IMP3 expression was related to various clinicopathologic factors. IMP3 expression was an independent prognostic factor in patients with OSCC.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.21457/abstract
DOI
10.1002/hed.21457
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Kim, Jin(김진)
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
Nam, Woong(남웅) ORCID logo https://orcid.org/0000-0003-0146-3624
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
Cha, Jeong Dan(차정단)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92992
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