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Molecular Subtypes and Tumor Response to Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer

DC Field Value Language
dc.contributor.author구자승-
dc.contributor.author김승일-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author박형석-
dc.contributor.author손주혁-
dc.date.accessioned2014-12-20T16:30:12Z-
dc.date.available2014-12-20T16:30:12Z-
dc.date.issued2011-
dc.identifier.issn0030-2414-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92838-
dc.description.abstractObjective: Pathologic complete response (pCR) is the most predictive factor for patients with neoadjuvant chemotherapy and we investigated the rate of pCR according to molecular subtypes defined by immunohistochemical staining. Methods: Our subjects comprised 257 breast cancer patients who received 3 cycles of anthracycline/taxane-based neoadjuvant chemotherapy. The patients were classified into 4 subtypes: luminal A, luminal B, HER2 and triple negative. We analyzed the pCR rate and treatment outcome according to these subtypes. Results: Of a total of 257 patients, the pCR rate of luminal A, luminal B, HER2 and triple negative was 3.9, 5.0, 10.5 and 21.1%, respectively (p = 0.001). The 5-year disease-free survival of the pCR group (88.4%) was higher than that of the non-pCR group (65.6%), but it was not significant (p = 0.228). Among patients who have residual disease, the 5-year disease-free survival of luminal A, luminal B, HER2 and triple negative was 64.0, 65.7, 75.2 and 66.5%, respectively (p = 0.243). Triple negative and HER2 subtypes are more sensitive to neoadjuvant chemotherapy. Conclusion: To increase the pCR rate, type-specific approaches according to subtypes, such as an addition of trastuzumab, increasing the number of cycles or a novel regimen, should be considered.-
dc.description.statementOfResponsibilityopen-
dc.format.extent324~330-
dc.relation.isPartOfONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMolecular Subtypes and Tumor Response to Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorKim S.I.-
dc.contributor.googleauthorSohn J.-
dc.contributor.googleauthorKoo J.S.-
dc.contributor.googleauthorPark S.H.-
dc.contributor.googleauthorPark H.S.-
dc.contributor.googleauthorPark B.W.-
dc.identifier.doi10.1159/000322192-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA00658-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA01753-
dc.contributor.localIdA01995-
dc.relation.journalcodeJ02416-
dc.identifier.eissn1423-0232-
dc.identifier.urlhttp://www.karger.com/Article/FullText/322192-
dc.subject.keywordBreast cancer-
dc.subject.keywordMolecular subtype-
dc.subject.keywordNeoadjuvant chemotherapy-
dc.subject.keywordPathologic complete response-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameSohn, Joo Hyuk-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorPark, Hyung Seok-
dc.contributor.affiliatedAuthorSohn, Joo Hyuk-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsnot free-
dc.citation.volume79-
dc.citation.number5-6-
dc.citation.startPage324-
dc.citation.endPage330-
dc.identifier.bibliographicCitationONCOLOGY, Vol.79(5-6) : 324-330, 2011-
dc.identifier.rimsid28788-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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