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Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery.

DC FieldValueLanguage
dc.contributor.author심규원-
dc.contributor.author이준수-
dc.contributor.author강훈철-
dc.contributor.author김동석-
dc.contributor.author김세훈-
dc.contributor.author김윤희-
dc.contributor.author김흥동-
dc.date.accessioned2014-12-20T16:29:44Z-
dc.date.available2014-12-20T16:29:44Z-
dc.date.issued2011-
dc.identifier.issn0013-9580-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92823-
dc.description.abstractPURPOSE: The purpose of this study is to determine the sensibility of each imaging tool in identifying focal cortical dysplasia (FCD) in children and adolescents with epilepsy and to define the prognostic factors of pediatric and adolescent epilepsy surgery. METHODS: We identified 48 children with FCD who underwent resective surgery and analyzed their preoperative data. The results of various anatomic and functional neuroimaging studies were compared for accuracy in locating the lesion. We also investigated clinical factors that affected the outcome of surgical treatment. KEY FINDINGS: Brain magnetic resonance imaging (MRI) was able to localize FCD in 30 patients and fluorodeoxyglucose positron emission tomography (FDG-PET) and/or subtraction ictal single photon emission computed tomography (SPECT) coregistered with MRI provided additional information that helped to define the lesion in 13 patients. When comparing the pathologic results between a mild malformation of cortical development (MCD) and FCD type I and II, we noted a strong tendency for patients with FCD to have MRI abnormalities (p = 0.005). In addition, severe pathologic features (Palmini's classification, FCD type II) (p = 0.025) showed significant correlation with a better surgical outcome. To define the primary epileptogenic area, various interictal epileptiform discharges and the results of multimodal neuroimaging studies were helpful, and younger age at the time of operation could aid in more favorable surgical outcomes (p = 0.048). SIGNIFICANCE: Our study showed a significant relationship between pathologic grade and the detectability of FCD by brain MRI. In addition, early surgery can be justified by showing that advanced neuroimaging studies in children with FCD and even with extensive epileptiform discharges have a higher rate of success.-
dc.description.statementOfResponsibilityopen-
dc.format.extent722~727-
dc.relation.isPartOfEPILEPSIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHBrain Diseases/complications-
dc.subject.MESHBrain Diseases/diagnosis-
dc.subject.MESHBrain Diseases/surgery-
dc.subject.MESHBrain Mapping/methods-
dc.subject.MESHCerebral Cortex/diagnostic imaging-
dc.subject.MESHCerebral Cortex/pathology*-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHEpilepsy/diagnosis*-
dc.subject.MESHEpilepsy/etiology*-
dc.subject.MESHEpilepsy/surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMagnetic Resonance Imaging/methods-
dc.subject.MESHMale-
dc.subject.MESHMalformations of Cortical Development/complications-
dc.subject.MESHMalformations of Cortical Development/diagnosis-
dc.subject.MESHMalformations of Cortical Development/surgery-
dc.subject.MESHMalformations of Cortical Development, Group I-
dc.subject.MESHPositron-Emission Tomography/methods-
dc.subject.MESHPrognosis-
dc.subject.MESHYoung Adult-
dc.titleNeuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorYoon Hee Kim-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorDong-Seok Kim-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorKyu-Won Shim-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorJoon Soo Lee-
dc.identifier.doi10.1111/j.1528-1167.2010.02950.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02187-
dc.contributor.localIdA03177-
dc.contributor.localIdA00102-
dc.contributor.localIdA00402-
dc.contributor.localIdA00610-
dc.contributor.localIdA00799-
dc.contributor.localIdA01208-
dc.relation.journalcodeJ00793-
dc.identifier.eissn1528-1167-
dc.identifier.pmid21275980-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2010.02950.x/abstract-
dc.subject.keywordNeuroimaging-
dc.subject.keywordCortical dysplasia-
dc.subject.keywordPediat-ric and adolescent epilepsy surgery.-
dc.contributor.alternativeNameShim, Kyu Won-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Yoon Hee-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.affiliatedAuthorShim, Kyu Won-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.contributor.affiliatedAuthorKang, Hoon Chul-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Yoon Hee-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.rights.accessRightsnot free-
dc.citation.volume52-
dc.citation.number4-
dc.citation.startPage722-
dc.citation.endPage727-
dc.identifier.bibliographicCitationEPILEPSIA, Vol.52(4) : 722-727, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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