Cited 55 times in
Chromosome-encoded AmpC and CTX-M extended-spectrum β-lactamases in clinical isolates of Proteus mirabilis from Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주원 | - |
dc.contributor.author | 배일권 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2014-12-20T16:27:53Z | - |
dc.date.available | 2014-12-20T16:27:53Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92765 | - |
dc.description.abstract | Among 222 Proteus mirabilis clinical isolates collected from 17 hospitals in Korea in 2008, 28 (12.6%) and 8 (3.6%) isolates exhibited extended-spectrum β-lactamase (ESBL) and AmpC phenotypes, respectively. The most common type of ESBL gene identified by PCR and sequencing experiments was bla(CTX-M-14a) (n = 12). The bla(CTX-M-90) (n = 4), bla(CTX-M-15) (n = 3), bla(CTX-M-12) (n = 3), bla(CTX-M-2) (n = 2), bla(CTX-M-14b) (n = 1), bla(TEM-52) (n = 5), and bla(SHV-12) (n = 1) genes were also detected. Eight isolates carried an AmpC β-lactamase gene, such as bla(CMY-2) (n = 6) or bla(DHA-1) (n = 2). All bla genes encoding CTX-M-1- and CTX-M-9-type enzymes and all bla(CMY-2) genes were preceded by ISEcp1-like elements. The bla(CTX-M-2) gene found in two isolates was located on a complex class 1 integron. The bla(DHA-1) gene was preceded by a transcriptional regulator gene and was followed by phage shock protein genes. The bla(CTX-M) genes were located on the chromosome in 21 isolates. A plasmid location for the bla(CTX-M) gene was found in only four isolates: the bla(CTX-M-14a) gene was located on ∼150-kbp IncA/C plasmids in three isolates and on a ∼50-kbp IncN plasmid in one isolate. The bla(TEM-52) gene was located on ∼50-kbp IncN plasmids in all five isolates. The AmpC β-lactamase genes were located on the chromosome in seven of eight isolates; one isolate carried the bla(CMY-2) gene on a ∼150-kbp IncA/C plasmid. Our results show that a chromosomal location of CTX-M ESBL and AmpC β-lactamase genes in P. mirabilis is no longer an unusual phenomenon in hospital environments. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1414~1419 | - |
dc.relation.isPartOf | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology | - |
dc.subject.MESH | Bacterial Proteins/genetics* | - |
dc.subject.MESH | Blotting, Southern | - |
dc.subject.MESH | Chromosomes, Bacterial/genetics* | - |
dc.subject.MESH | Clavulanic Acid/pharmacology | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Plasmids/genetics | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Proteus mirabilis/drug effects | - |
dc.subject.MESH | Proteus mirabilis/enzymology* | - |
dc.subject.MESH | Proteus mirabilis/genetics | - |
dc.subject.MESH | beta-Lactamases/genetics* | - |
dc.title | Chromosome-encoded AmpC and CTX-M extended-spectrum β-lactamases in clinical isolates of Proteus mirabilis from Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Wonkeun Song | - |
dc.contributor.googleauthor | Juwon Kim | - |
dc.contributor.googleauthor | Il Kwon Bae | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Young Hee Seo | - |
dc.contributor.googleauthor | Jong Hee Shin | - |
dc.contributor.googleauthor | Sook Jin Jang | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Jeong Hwan Shin | - |
dc.contributor.googleauthor | Mi-Kyoung Lee | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.identifier.doi | 10.1128/AAC.01835-09 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00943 | - |
dc.contributor.localId | A01802 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00189 | - |
dc.identifier.eissn | 1098-6596 | - |
dc.identifier.pmid | 21282448 | - |
dc.contributor.alternativeName | Kim, Ju Won | - |
dc.contributor.alternativeName | Bae, Il Kwon | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Ju Won | - |
dc.contributor.affiliatedAuthor | Bae, Il Kwon | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 55 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1414 | - |
dc.citation.endPage | 1419 | - |
dc.identifier.bibliographicCitation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.55(4) : 1414-1419, 2011 | - |
dc.identifier.rimsid | 28745 | - |
dc.type.rims | ART | - |
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