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Immunotherapeutic restoration in HIV-infected individuals

Authors
 June Myung Kim ; Sang Hoon Han 
Citation
 Immunotherapy, Vol.3(2) : 247~267, 2011 
Journal Title
 Immunotherapy 
ISSN
 1750-743X 
Issue Date
2011
Abstract
While the development of combined active antiretroviral therapy (cART) has dramatically improved life expectancies and quality of life in HIV-infected individuals, long-term clinical problems, such as metabolic complications, remain important constraints of life-long cART. Complete immune restoration using only cART is normally unattainable even in cases of sufficient plasma viral suppression. The need for immunologic adjuncts that complement cART remains, because while cART alone may result in the complete recovery of peripheral net CD4+ T lymphocytes, it may not affect the reservoir of HIV-infected cells. Here, we review current immunotherapies for HIV infection, with a particular emphasis on recent advances in cytokine therapies, therapeutic immunization, monoclonal antibodies, immune-modulating drugs, nanotechnology-based approaches and radioimmunotherapy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92744
DOI
10.2217/IMT.10.91
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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