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Vascular endothelial growth factor, soluble fms-like tyrosine kinase 1, and the severity of coronary artery disease

 Yangsoo Jang  ;  Ichiro Manabe  ;  Sun Ha Jee  ;  Seung-Yun Cho  ;  Won-Heum Shim  ;  Namsik Chung  ;  Seok-Min Kang  ;  Sungha Park  ;  Sang-Hak Lee  ;  Soo-Young Kim 
 ANGIOLOGY, Vol.62(2) : 176-183, 2011 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cohort Studies ; Coronary Angiography ; Coronary Artery Disease/blood* ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Female ; Humans ; Hypertension/blood ; Hypertension/complications ; Hypertension/diagnosis ; Male ; Middle Aged ; Risk Factors ; Severity of Illness Index ; Vascular Endothelial Growth Factor A/blood* ; Vascular Endothelial Growth Factor Receptor-1/blood*
atherosclerosis ;  coronary artery disease ;  vascular endothelial growth factors ;  vascular endothelial growth factor receptor 1
BACKGROUND: The association between vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and coronary artery disease (CAD) was investigated. METHODS: We enrolled 112 hypertensive patients with proven CAD and 112 hypertensive controls matched for age and gender. The severity of CAD was assessed by the most severe clinical presentation of CAD in patients' history and by the number of diseased vessels. RESULTS: Vascular endothelial growth factor level was lower, whereas sFlt-1 level was higher in the CAD group compared to the controls. Diabetes mellitus (P = .001), smoking (P = .004), and higher sFlt-1 level (P = .01) were independently associated with CAD. Younger age (P = .02), smoking (P = .049), and higher VEGF levels (P = .02) were independently associated with a history of myocardial infarction (MI), whereas higher sFlt-1 level (P = .01) was independently associated with multivessel disease. CONCLUSION: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD
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4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Won Heum(심원흠)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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