Cited 12 times in

88 4

Vascular endothelial growth factor, soluble fms-like tyrosine kinase 1, and the severity of coronary artery disease

Authors
 Yangsoo Jang ; Ichiro Manabe ; Soo-Young Kim ; Sang-Hak Lee ; Sungha Park ; Seok-Min Kang ; Namsik Chung ; Won-Heum Shim ; Seung-Yun Cho ; Sun Ha Jee 
Citation
 Angiology, Vol.62(2) : 176~183, 2011 
Journal Title
 Angiology 
ISSN
 0003-3197 
Issue Date
2011
Abstract
BACKGROUND: The association between vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and coronary artery disease (CAD) was investigated. METHODS: We enrolled 112 hypertensive patients with proven CAD and 112 hypertensive controls matched for age and gender. The severity of CAD was assessed by the most severe clinical presentation of CAD in patients' history and by the number of diseased vessels. RESULTS: Vascular endothelial growth factor level was lower, whereas sFlt-1 level was higher in the CAD group compared to the controls. Diabetes mellitus (P = .001), smoking (P = .004), and higher sFlt-1 level (P = .01) were independently associated with CAD. Younger age (P = .02), smoking (P = .049), and higher VEGF levels (P = .02) were independently associated with a history of myocardial infarction (MI), whereas higher sFlt-1 level (P = .01) was independently associated with multivessel disease. CONCLUSION: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92709
DOI
10.1177/0003319710370963
Appears in Collections:
1. 연구논문 > 4. Graduate School of Public Health > Graduate School of Public Health
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://ang.sagepub.com/content/62/2/176
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse