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Vascular endothelial growth factor, soluble fms-like tyrosine kinase 1, and the severity of coronary artery disease

Authors
 Yangsoo Jang  ;  Ichiro Manabe  ;  Sun Ha Jee  ;  Seung-Yun Cho  ;  Won-Heum Shim  ;  Namsik Chung  ;  Seok-Min Kang  ;  Sungha Park  ;  Sang-Hak Lee  ;  Soo-Young Kim 
Citation
 Angiology, Vol.62(2) : 176-183, 2011 
Journal Title
 Angiology 
ISSN
 0003-3197 
Issue Date
2011
Abstract
BACKGROUND: The association between vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and coronary artery disease (CAD) was investigated. METHODS: We enrolled 112 hypertensive patients with proven CAD and 112 hypertensive controls matched for age and gender. The severity of CAD was assessed by the most severe clinical presentation of CAD in patients' history and by the number of diseased vessels. RESULTS: Vascular endothelial growth factor level was lower, whereas sFlt-1 level was higher in the CAD group compared to the controls. Diabetes mellitus (P = .001), smoking (P = .004), and higher sFlt-1 level (P = .01) were independently associated with CAD. Younger age (P = .02), smoking (P = .049), and higher VEGF levels (P = .02) were independently associated with a history of myocardial infarction (MI), whereas higher sFlt-1 level (P = .01) was independently associated with multivessel disease. CONCLUSION: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92709
Full Text
http://ang.sagepub.com/content/62/2/176
DOI
10.1177/0003319710370963
Appears in Collections:
1. Journal Papers (연구논문) > 4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강석민(Kang, Seok Min) ORCID logo https://orcid.org/0000-0001-9856-9227
박성하(Park, Sung Ha) ORCID logo https://orcid.org/0000-0001-5362-478X
심원흠(Shim, Won Heum)
이상학(Lee, Sang Hak) ORCID logo https://orcid.org/0000-0002-4535-3745
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
정남식(Chung, Nam Sik)
조승연(Cho, Seung Yun)
지선하(Jee, Sun Ha)
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