4 261

Cited 0 times in

Vascular endothelial growth factor, soluble fms-like tyrosine kinase 1, and the severity of coronary artery disease

Authors
 Yangsoo Jang  ;  Ichiro Manabe  ;  Sun Ha Jee  ;  Seung-Yun Cho  ;  Won-Heum Shim  ;  Namsik Chung  ;  Seok-Min Kang  ;  Sungha Park  ;  Sang-Hak Lee  ;  Soo-Young Kim 
Citation
 Angiology, Vol.62(2) : 176-183, 2011 
Journal Title
 Angiology 
ISSN
 0003-3197 
Issue Date
2011
Abstract
BACKGROUND: The association between vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase 1 (sFlt-1), and coronary artery disease (CAD) was investigated. METHODS: We enrolled 112 hypertensive patients with proven CAD and 112 hypertensive controls matched for age and gender. The severity of CAD was assessed by the most severe clinical presentation of CAD in patients' history and by the number of diseased vessels. RESULTS: Vascular endothelial growth factor level was lower, whereas sFlt-1 level was higher in the CAD group compared to the controls. Diabetes mellitus (P = .001), smoking (P = .004), and higher sFlt-1 level (P = .01) were independently associated with CAD. Younger age (P = .02), smoking (P = .049), and higher VEGF levels (P = .02) were independently associated with a history of myocardial infarction (MI), whereas higher sFlt-1 level (P = .01) was independently associated with multivessel disease. CONCLUSION: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD
Full Text
http://ang.sagepub.com/content/62/2/176
DOI
10.1177/0003319710370963
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Won Heum(심원흠)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92709
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse