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The effects of statin monotherapy and low-dose statin/ezetimibe on lipoprotein-associated phospholipase A₂

DC FieldValueLanguage
dc.contributor.author강석민-
dc.contributor.author박성하-
dc.contributor.author이상학-
dc.contributor.author장양수-
dc.contributor.author정남식-
dc.contributor.author최동훈-
dc.date.accessioned2014-12-20T16:26:01Z-
dc.date.available2014-12-20T16:26:01Z-
dc.date.issued2011-
dc.identifier.issn0160-9289-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92707-
dc.description.abstractBACKGROUND: Many of the pleiotropic effects of statins remain to be elucidated. HYPOTHESIS: Different statin regimens with similar lipid-lowering efficacy may have different effects on biomarkers of atherothrombosis including lipoprotein-associated phospholipase A₂ (Lp-PLA₂ ). METHODS: After a 4-week dietary lead-in, 82 hypercholesterolemic patients were randomized to 1 of 2 treatment groups: atorvastatin 20 mg or atorvastatin/ezetimibe 5 mg/5 mg. After 8 weeks of drug treatment, the groups were compared for percent change in lipid parameters, Lp-PLA₂ , interleukin-6 (IL-6), monocyte chemoattractant protein-1, and fibrinogen. RESULTS: Low-density lipoprotein cholesterol (LDL-C) lowering was comparable between the 2 groups (-47% ± 11% and -49% ± 7% in the atorvastatin and combination groups, respectively). Although Lp-PLA₂ was reduced in both groups, the reduction was greater in the atorvastatin group (-42% and -9% [median], respectively, P = 0.03). Although IL-6 was decreased only in the atorvastatin group, IL-6 changes were not significantly different between the 2 groups. The changes in monocyte chemoattractant protein-1 and fibrinogen were similar in each group. CONCLUSIONS: Atorvastatin monotherapy was stronger at reducing plasma Lp-PLA₂ than the low-dose atorvastatin/ezetimibe combination after equivalent LDL-C lowering. This result may provide evidence of potential statin effects beyond the lowering of LDL-C.-
dc.description.statementOfResponsibilityopen-
dc.format.extent108~112-
dc.relation.isPartOfClinical Cardiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH1-Alkyl-2-acetylglycerophosphocholine Esterase/blood*-
dc.subject.MESH1-Alkyl-2-acetylglycerophosphocholine Esterase/drug effects-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnticholesteremic Agents/administration & dosage-
dc.subject.MESHAnticholesteremic Agents/therapeutic use*-
dc.subject.MESHAtorvastatin Calcium-
dc.subject.MESHAzetidines/administration & dosage-
dc.subject.MESHAzetidines/therapeutic use*-
dc.subject.MESHBiomarkers, Pharmacological/blood-
dc.subject.MESHChemokine CCL2/metabolism-
dc.subject.MESHCholesterol, LDL/blood-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHEzetimibe-
dc.subject.MESHFemale-
dc.subject.MESHFibrinogen/metabolism-
dc.subject.MESHHeptanoic Acids/administration & dosage-
dc.subject.MESHHeptanoic Acids/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use*-
dc.subject.MESHHypercholesterolemia/blood-
dc.subject.MESHHypercholesterolemia/drug therapy*-
dc.subject.MESHInterleukin-6/blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPyrroles/administration & dosage-
dc.subject.MESHPyrroles/therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleThe effects of statin monotherapy and low-dose statin/ezetimibe on lipoprotein-associated phospholipase A₂-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorDonghoon Choi-
dc.identifier.doi10.1002/clc.20853-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.contributor.localIdA01512-
dc.contributor.localIdA03448-
dc.contributor.localIdA03585-
dc.contributor.localIdA04053-
dc.contributor.localIdA02833-
dc.relation.journalcodeJ00565-
dc.identifier.pmid21298654-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/clc.20853/abstract-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameLee, Sang Hak-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.rights.accessRightsnot free-
dc.citation.volume34-
dc.citation.number2-
dc.citation.startPage108-
dc.citation.endPage112-
dc.identifier.bibliographicCitationClinical Cardiology, Vol.34(2) : 108-112, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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