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Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear

Authors
 Jinwoong Bok  ;  Steven Raft  ;  Kyoung-Ah Kong  ;  Soo Kyung Koo  ;  Ursula C. Dräger  ;  Doris K. Wu 
Citation
 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.108(1) : 161-166, 2011 
Journal Title
 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 
ISSN
 0027-8424 
Issue Date
2011
MeSH
Animals ; Body Patterning/physiology* ; Chick Embryo ; Cycloheximide ; Ear, Inner/embryology* ; Gene Expression Regulation, Developmental/genetics ; Gene Expression Regulation, Developmental/physiology* ; In Situ Hybridization ; Mice ; Microspheres ; Signal Transduction/physiology* ; T-Box Domain Proteins/metabolism* ; Tretinoin/metabolism* ; beta-Galactosidase
Keywords
axial specification ; developmental compartments ; morphogen
Abstract
Vertebrate hearing and balance are based in complex asymmetries of inner ear structure. Here, we identify retinoic acid (RA) as an extrinsic signal that acts directly on the ear rudiment to affect its compartmentalization along the anterior-posterior axis. A rostrocaudal wave of RA activity, generated by tissues surrounding the nascent ear, induces distinct responses from anterior and posterior halves of the inner ear rudiment. Prolonged response to RA by posterior otic tissue correlates with Tbx1 transcription and formation of mostly nonsensory inner ear structures. By contrast, anterior otic tissue displays only a brief response to RA and forms neuronal elements and most sensory structures of the inner ear
Files in This Item:
T201100326.pdf Download
DOI
10.1073/pnas.1010547108
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kong, Kyoung Ah(공경아)
Bok, Jin Woong(복진웅) ORCID logo https://orcid.org/0000-0003-1958-1872
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92699
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