Cited 22 times in
The cyclic pentapeptide d-Arg3FC131, a CXCR4 antagonist, induces apoptosis of somatotrope tumor and inhibits tumor growth in nude mice.
DC Field | Value | Language |
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dc.contributor.author | 구철룡 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2014-12-20T16:23:25Z | - |
dc.date.available | 2014-12-20T16:23:25Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92625 | - |
dc.description.abstract | The interaction between the chemokine stromal cell-derived factor 1 and its receptor CXCR4 plays an important role in GH production and cell proliferation in normal and tumorous pituitary somatotrope cells. Therefore, the chemokine receptor CXCR4 could be an attractive target for antitumor drugs in patients with acromegaly. A synthetic antagonist of CXCR4, cyclic pentapeptide d-Arg3FC131 (c[Gly1-d-Tyr2-d-Arg3-Arg4-Nal5]) significantly inhibited GH production and proliferation of GH3 somatotrope tumor cells in vitro. It also induced apoptosis of GH3 cells through activation of the caspase-3 pathway. Systemic administration of d-Arg3FC131 inhibited the growth of GH3 cell xenografts in immunodeficient nude mice by inducing apoptosis and suppressing the proliferation of tumor cells. These results indicate that d-Arg3FC131 might have potential for the treatment of pituitary tumors producing excess GH in patients with acromegaly. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 536~544 | - |
dc.relation.isPartOf | ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoviridae | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Genetic Vectors/genetics | - |
dc.subject.MESH | Growth Hormone/metabolism | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Oligopeptides/pharmacology* | - |
dc.subject.MESH | Peptides, Cyclic/pharmacology* | - |
dc.subject.MESH | Peptides, Cyclic/therapeutic use | - |
dc.subject.MESH | Pituitary Neoplasms/drug therapy* | - |
dc.subject.MESH | Pituitary Neoplasms/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Receptors, CXCR4/antagonists & inhibitors* | - |
dc.subject.MESH | Receptors, CXCR4/therapeutic use | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Somatotrophs/drug effects* | - |
dc.subject.MESH | Somatotrophs/pathology* | - |
dc.title | The cyclic pentapeptide d-Arg3FC131, a CXCR4 antagonist, induces apoptosis of somatotrope tumor and inhibits tumor growth in nude mice. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jeong Mo Kim | - |
dc.contributor.googleauthor | Yong-ho Lee | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1210/en.2010-0642 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J00772 | - |
dc.identifier.eissn | 1945-7170 | - |
dc.identifier.pmid | 21147876 | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Ku, Cheol Ryong | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 152 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 536 | - |
dc.citation.endPage | 544 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY, Vol.152(2) : 536-544, 2011 | - |
dc.identifier.rimsid | 28662 | - |
dc.type.rims | ART | - |
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