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Cited 22 times in

The cyclic pentapeptide d-Arg3FC131, a CXCR4 antagonist, induces apoptosis of somatotrope tumor and inhibits tumor growth in nude mice.

DC Field Value Language
dc.contributor.author구철룡-
dc.contributor.author이용호-
dc.contributor.author이은직-
dc.date.accessioned2014-12-20T16:23:25Z-
dc.date.available2014-12-20T16:23:25Z-
dc.date.issued2011-
dc.identifier.issn0013-7227-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92625-
dc.description.abstractThe interaction between the chemokine stromal cell-derived factor 1 and its receptor CXCR4 plays an important role in GH production and cell proliferation in normal and tumorous pituitary somatotrope cells. Therefore, the chemokine receptor CXCR4 could be an attractive target for antitumor drugs in patients with acromegaly. A synthetic antagonist of CXCR4, cyclic pentapeptide d-Arg3FC131 (c[Gly1-d-Tyr2-d-Arg3-Arg4-Nal5]) significantly inhibited GH production and proliferation of GH3 somatotrope tumor cells in vitro. It also induced apoptosis of GH3 cells through activation of the caspase-3 pathway. Systemic administration of d-Arg3FC131 inhibited the growth of GH3 cell xenografts in immunodeficient nude mice by inducing apoptosis and suppressing the proliferation of tumor cells. These results indicate that d-Arg3FC131 might have potential for the treatment of pituitary tumors producing excess GH in patients with acromegaly.-
dc.description.statementOfResponsibilityopen-
dc.format.extent536~544-
dc.relation.isPartOfENDOCRINOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenoviridae-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCell Line-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHGenetic Vectors/genetics-
dc.subject.MESHGrowth Hormone/metabolism-
dc.subject.MESHIn Situ Nick-End Labeling-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHOligopeptides/pharmacology*-
dc.subject.MESHPeptides, Cyclic/pharmacology*-
dc.subject.MESHPeptides, Cyclic/therapeutic use-
dc.subject.MESHPituitary Neoplasms/drug therapy*-
dc.subject.MESHPituitary Neoplasms/metabolism-
dc.subject.MESHRats-
dc.subject.MESHReceptors, CXCR4/antagonists & inhibitors*-
dc.subject.MESHReceptors, CXCR4/therapeutic use-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSomatotrophs/drug effects*-
dc.subject.MESHSomatotrophs/pathology*-
dc.titleThe cyclic pentapeptide d-Arg3FC131, a CXCR4 antagonist, induces apoptosis of somatotrope tumor and inhibits tumor growth in nude mice.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJeong Mo Kim-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorCheol Ryong Ku-
dc.contributor.googleauthorEun Jig Lee-
dc.identifier.doi10.1210/en.2010-0642-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00201-
dc.contributor.localIdA02989-
dc.contributor.localIdA03050-
dc.relation.journalcodeJ00772-
dc.identifier.eissn1945-7170-
dc.identifier.pmid21147876-
dc.contributor.alternativeNameKu, Cheol Ryong-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.affiliatedAuthorKu, Cheol Ryong-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.rights.accessRightsfree-
dc.citation.volume152-
dc.citation.number2-
dc.citation.startPage536-
dc.citation.endPage544-
dc.identifier.bibliographicCitationENDOCRINOLOGY, Vol.152(2) : 536-544, 2011-
dc.identifier.rimsid28662-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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