Cited 29 times in
Carbapenem-non-susceptible Acinetobacter baumannii of sequence type 92 or its single-locus variants with a G428T substitution in zone 2 of the rpoB gene
DC Field | Value | Language |
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dc.contributor.author | 정석훈 | - |
dc.contributor.author | 배일권 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 이양순 | - |
dc.contributor.author | 이종한 | - |
dc.date.accessioned | 2014-12-20T16:21:19Z | - |
dc.date.available | 2014-12-20T16:21:19Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92561 | - |
dc.description.abstract | OBJECTIVES: to investigate the epidemiological traits of carbapenem-non-susceptible Acinetobacter baumannii (CNSAB) and the usefulness of phylogenetic grouping based on partial rpoB gene sequencing in defining the epidemiological traits of CNSAB. METHODS: a total of 547 non-duplicate clinical isolates of Acinetobacter spp. were collected from 19 hospitals in Korea in 2008. Detection of genes encoding OXA carbapenemases and metallo-β-lactamases was performed by PCR. The epidemiological relationships of the isolates were investigated by multilocus sequence typing and repetitive-sequence-based PCR. The 450 bp sequence (zone 2) of the rpoB gene was amplified and sequenced. RESULTS: molecular characterization of the 272 CNSAB isolates identified five sequence types (STs): ST92, ST75, ST137, ST138 and ST69. The first four of these STs were clustered into clonal complex (CC) 92, sharing alleles at six of seven housekeeping gene loci; ST69 shared alleles at five of seven loci. CNSAB of CC92 carried the bla(OXA-23) gene (n = 169), the bla(OXA-51)-like gene preceded by ISAba1 (n = 89) or both (n = 14). Notably, all CNSAB isolates carried a G428T substitution in zone 2 of the rpoB gene. CONCLUSIONS: CNSAB isolates of CC92 with the G428T substitution in zone 2 of the rpoB gene are disseminated nationwide in Korea. A. baumannii with the single nucleotide substitution may be more likely to acquire carbapenem resistance than are other isolates. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 66~72 | - |
dc.relation.isPartOf | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acinetobacter Infections/microbiology | - |
dc.subject.MESH | Acinetobacter baumannii/classification* | - |
dc.subject.MESH | Acinetobacter baumannii/genetics | - |
dc.subject.MESH | Acinetobacter baumannii/isolation & purification | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology* | - |
dc.subject.MESH | Bacterial Proteins/genetics | - |
dc.subject.MESH | Bacterial Typing Techniques* | - |
dc.subject.MESH | Carbapenems/pharmacology* | - |
dc.subject.MESH | Cluster Analysis | - |
dc.subject.MESH | Cross Infection/microbiology | - |
dc.subject.MESH | DNA, Bacterial/genetics | - |
dc.subject.MESH | DNA-Directed RNA Polymerases/genetics* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Hospitals | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Molecular Epidemiology/methods | - |
dc.subject.MESH | Multilocus Sequence Typing* | - |
dc.subject.MESH | Phylogeny | - |
dc.subject.MESH | Polymerase Chain Reaction/methods | - |
dc.subject.MESH | beta-Lactamases/genetics | - |
dc.title | Carbapenem-non-susceptible Acinetobacter baumannii of sequence type 92 or its single-locus variants with a G428T substitution in zone 2 of the rpoB gene | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yangsoon Lee | - |
dc.contributor.googleauthor | Jinhwa Lee | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Jonghan Lee | - |
dc.contributor.googleauthor | Il Kwon Bae | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.identifier.doi | 10.1093/jac/dkq402 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03619 | - |
dc.contributor.localId | A01802 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A02947 | - |
dc.contributor.localId | A03151 | - |
dc.relation.journalcode | J01237 | - |
dc.identifier.eissn | 1460-2091 | - |
dc.identifier.pmid | 21051374 | - |
dc.subject.keyword | clonal complex 92 | - |
dc.subject.keyword | European clone II | - |
dc.subject.keyword | multilocus sequence typing | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.alternativeName | Bae, Il Kwon | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Lee, Yang Soon | - |
dc.contributor.alternativeName | Lee, Jong Han | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Bae, Il Kwon | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Lee, Yang Soon | - |
dc.contributor.affiliatedAuthor | Lee, Jong Han | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 66 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 72 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.66(1) : 66-72, 2011 | - |
dc.identifier.rimsid | 28634 | - |
dc.type.rims | ART | - |
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