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A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the bla(OXA-23) gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii

Authors
 Yangsoon Lee ; Chang-Ki Kim ; Kyungwon Lee ; Dongeun Yong ; Seok Hoon Jeong ; Hyukmin Lee 
Citation
 Antimicrobial Agents and Chemotherapy, Vol.55(1) : 361~363, 2011 
Journal Title
 Antimicrobial Agents and Chemotherapy 
ISSN
 0066-4804 
Issue Date
2011
Abstract
We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the bla(OXA-23) gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the bla(OXA-23) gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92548
DOI
10.1128/AAC.01672-09
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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