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항p200 유사천포창

Other Titles
 Anti-p200 Pemphigoid. 
Authors
 이명훈 ; 유지영 ; 김수찬 ; 장태정 ; 서무규 
Citation
 대한피부과학회지, Vol.50(10) : 912~916, 2012 
Journal Title
 대한피부과학회지 
ISSN
 4944-4739 
Issue Date
2012
Abstract
Anti-p200 pemphigoid is an autoimmune subepidermal bullous disease characterized by circulating and tissue-bound autoantibodies directed against a 200 kD protein of the human dermis. We report a 78-year-old male who was presented with bullous eruptions on the trunk, extremities, which clinically resemble bullous pemphigoid, epidermolysis bullosa aquisita, linear IgA dermatosis or dermatitis herpetiformis. Oral muscosa of the lower lip was also affected. Histopathological examination of a skin biopsy specimen from the trunk revealed subepidermal blister and infiltration predominantly by neutrophils. Direct immunofluorescence revealed linear deposits of IgG, C3 and IgA at the basement membrane zone. Indirect immunofluorescence using salt-split skin showed that IgG antibodies bound on the dermal side. Immunoblotting with dermal extracts showed that the patient's IgG autoantibodies reacted with a 200 kD protein. The patient showed good response to dapsone.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92403
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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