한국 성인의 베타세포 기능과 영양소 섭취와의 관련성 - 2009년 국민건강영양조사 자료를 이용하여-

Abstract

The purpose of this study was to evaluate pancreatic β-cell function of Korean adult and to examine the associations between β-cell function and nutrient intakes. Data were analyzed for 1,917 male and 2,885 female subjects older than 30 years using 'The Forth Korean National Health and Nutrition Survey in 2009'. We calculated HOMA β-cell (The homeostasis model assessment of β-cell function) using fasting glucose and fasting insulin for assessing β-cell function. Subjects were divided into HHG (High HOMA β-cell Group) or LHG (Low HOMA β-cell Group) according to median of HOMA β-cell, and then nutrient intakes were compared between two groups. In the entire study population, HHG showed lower percent of carbohydrate intakes (p < 0.05), and higher fat (p < 0.01), percent of fat (p < 0.05), vitamin A (p < 0.05), carotene (p < 0.05) and riboflavin (p < 0.05) intakes than LHG. In addition, levels of HOMA β-cell were negatively correlated with percent of carbohydrate (β = -0.040, p < 0.05), and positively correlated with percent of fat (β = 0.046, p < 0.01). The subjects were then divided into two subgroups according to body mass index values, either < 23 kg/m2 (under- and normal-weight) or ≥ 23 kg/m2 (over-weight and obese). Significant differences of some nutrients intakes and correlations with HOMA β-cell were observed only in under- and normal weight subjects, but not in over-weight and obese subjects. In conclusion, high carbohydrate, lower fat and lower vitamin intakes may be related with pancreatic β-cell dysfunction in under- and normal-weight Korean.