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신장이식 1개월 이후 AdvagrafⓇ (Extended Release Tacrolimus)와 PrografⓇ (Tacrolimus)의 유효성 및 안전성을 비교 평가하기 위한 공개, 평행, 다기관 임상시험: 중간 연구 보고
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 조홍래 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2014-12-19T17:55:43Z | - |
dc.date.available | 2014-12-19T17:55:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1298-1711 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92323 | - |
dc.description.abstract | Background: Compliance from kidney transplant recipients might improve with less frequent doses of immunosuppressant drugs. We describe the development of an extended-release formulation of tacrolimus that enables taking the drug just once a day, instead of the current twice a day tacrolimus formulation. Methods: We performed a prospective, open-label, 1:1 randomized, and multicenter study. Patients received PrografⓇ (Astellas Inc.) twice a day for 1 month post-transplantation. The patients of the investigational group converted to a dose of AdvagrafⓇ (Astellas Inc.) given once a day. We evaluated the efficacy, safety, and patient satisfaction of both groups. Results: Within 5 months after conversion to Advagraf, the incidence of biopsy-confirmed acute rejection was 0%, while patient and graft survival was 100%. We could not find differences of the patients' estimated glomerular filtration rate (eGFR) between the Prograf and Advagraf treated groups 1∼6 months post-transplantation. The safety profile and satisfaction profiles (immunosuppressant therapy barrier scale) were also equivalent between the treated groups. Conclusions: The preliminary results of this study support the safety, efficacy, and patient satisfaction from a single daily formulation of tacrolimus (AdvagrafⓇ). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 254~260 | - |
dc.language | Journal of the Korean Society for Transplantation | - |
dc.publisher | Journal of the Korean Society for Transplantation | - |
dc.relation.isPartOf | Journal of the Korean Society for Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 신장이식 1개월 이후 AdvagrafⓇ (Extended Release Tacrolimus)와 PrografⓇ (Tacrolimus)의 유효성 및 안전성을 비교 평가하기 위한 공개, 평행, 다기관 임상시험: 중간 연구 보고 | - |
dc.title.alternative | Multicenter Clinical Investigation for the Safety and Efficacy of Advagraf® (Extended Release Tacrolimus) versus Prograf® (Tacrolimus) in De Novo Kidney Recipients after 1 Month of Transplantation: Preliminary Results | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | 이종훈 | - |
dc.contributor.googleauthor | 허규하 | - |
dc.contributor.googleauthor | 이종수 | - |
dc.contributor.googleauthor | 오창권 | - |
dc.contributor.googleauthor | 조홍래 | - |
dc.contributor.googleauthor | 김유선 | - |
dc.identifier.doi | 10.4285/jkstn.2012.26.4.254 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A03943 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J01858 | - |
dc.identifier.eissn | 2508-2604 | - |
dc.identifier.pmid | Kidney transplantation ; Immunosuppression ; Extended-release tacrolimus ; Kidney graft function ; Rejection | - |
dc.subject.keyword | Kidney transplantation | - |
dc.subject.keyword | Immunosuppression | - |
dc.subject.keyword | Extended-release tacrolimus | - |
dc.subject.keyword | Kidney graft function | - |
dc.subject.keyword | Rejection | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Cho, Hong Rae | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Cho, Hong Rae | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 254 | - |
dc.citation.endPage | 260 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Transplantation, Vol.26(4) : 254-260, 2012 | - |
dc.identifier.rimsid | 29417 | - |
dc.type.rims | ART | - |
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