We present the case of a 50-year-old male kidney transplant recipient whose verruca skin warts completely disappeared after conversion of immunosuppressive treatment from cyclosporine A to sirolimus. Before conversion, the patient underwent three sessions of cryotherapy, but this treatment failed to produce noticeable improvement in wart number or severity. In this case of a transplant recipient under CsA-based immunosuppression, change of immunosuppressive treatment to sirolimus produced dramatic improvement in the elimination of verruca warts.