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Duchenne 근디스트로피의 치료에 대한 고찰
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박형준 | - |
dc.contributor.author | 최영철 | - |
dc.date.accessioned | 2014-12-19T17:54:06Z | - |
dc.date.available | 2014-12-19T17:54:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92271 | - |
dc.description.abstract | Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder due to the loss of dystrophin in muscle fiber. The deficiency of dystrophin produces severe progressive muscle degeneration which leads to progressive muscle weakness. Affected patients usually become unambulatory in their early teens, and suffer a respiratory failure before 20 years of age. In an attempt to improve quality of life and extend life span of DMD patients, various treatments have been challenged; corticosteroid trial, rehabilitation, cardiac and pulmonary managements, orthopedic interventions, and nutritional support. However, only corticosteroid therapy and non-invasive ventilation have shown a salutary effect on the clinical course of DMD. Recently, a better understanding of the DMD pathophysiology has provided the scientific basis for new treatment modalities including cell and molecular therapy. Although previous clinical trials have demonstrated the limitation and possibility of new therapies, antisense-mediated exon skipping technology is now emerging as a promising approach to restore dystrophin expression. This article summarizes the current challenges and recommendations of treatment approaches in DMD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Journal of the Korean Neurological Association | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Duchenne 근디스트로피의 치료에 대한 고찰 | - |
dc.title.alternative | Treatment of Duchenne Muscular Dystrophy: A Comprehensive Review | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | 박형준 | - |
dc.contributor.googleauthor | 최영철 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01758 | - |
dc.contributor.localId | A04116 | - |
dc.relation.journalcode | J01835 | - |
dc.identifier.pmid | Cell therapy ; Corticosteroids ; Duchenne muscular dystrophy ; Gene therapy | - |
dc.subject.keyword | Cell therapy | - |
dc.subject.keyword | Corticosteroids | - |
dc.subject.keyword | Duchenne muscular dystrophy | - |
dc.subject.keyword | Gene therapy | - |
dc.contributor.alternativeName | Park, Hyung Jun | - |
dc.contributor.alternativeName | Choi, Young Chul | - |
dc.contributor.affiliatedAuthor | Park, Hyung Jun | - |
dc.contributor.affiliatedAuthor | Choi, Young Chul | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 257 | - |
dc.citation.endPage | 266 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Neurological Association, Vol.30(4) : 257-266, 2012 | - |
dc.identifier.rimsid | 29374 | - |
dc.type.rims | ART | - |
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