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Minimally Invasive Laser-Assisted Biopsy of the Oral Lesions for Oral Graft-Versus-Host Disease after Hematopoietic Stem-Cell Transplantation

Other Titles
 조혈줄기세포이식후 발생한 이식편대숙주병의 구강병소에 대한 최소침습적 레이저조직생검 증례 
Authors
 Yunmi Kim  ;  Hee-Jung Yun  ;  Hyun-Sil Kim  ;  Kee-Deog Kim  ;  Bock-Young Jung  ;  Nan-Sim Pang  ;  Wonse Park 
Citation
 Journal of Korean Academy of Oral Medicine (대한구강내과학회지), Vol.37(3) : 147-154, 2012 
Journal Title
Journal of Korean Academy of Oral Medicine(대한구강내과학회지)
ISSN
 1225-0627 
Issue Date
2012
Keywords
Allogenic bone marrow transplantation ; Biopsy ; Graft vs Host Disease ; Er ; Cr:YSGG lasers
Abstract
Hematopoietic stem-cell transplantation (HSCT) is a treatment for immune deficiency, autoimmune diseases, and hematopoietic malignancies. The main complication of allogenic HSCT is graft-versus-host disease (GVHD). Oral mucosal biopsy is needed for a definitive diagnosis and treatment planning of GVHD, but this procedure causes bleeding and bacteremia in a poor general condition. We evaluated the efficacy of laser-assisted biopsy as a minimally invasive treatment. Three cases were described in this article. All patients" medical records, clinical photographs, and histopathologic findings were reviewed. All patients felt comfortable and no severe complications occurred. The quality of the obtained biopsy material was adequate for a definitive diagnosis of GVHD. Laser-assisted, minimally invasive biopsy of the oral mucosa does not cause bleeding, and it reduces the chances of infection, bacteremia, and postoperative scarring compared to the usual histopathologic biopsy procedure. It would thus be advantageous to use this procedure to biopsy GVHD patients.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kee Deog(김기덕) ORCID logo https://orcid.org/0000-0003-3055-5130
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Pang, Nan Sim(방난심) ORCID logo https://orcid.org/0000-0003-4265-673X
Yun, Hee Jung(윤희정)
Jung, Bok Yeong(정복영) ORCID logo https://orcid.org/0000-0002-8186-2109
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92211
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