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Spinal Cord Hemangioblastomas in von Hippel-Lindau Disease: Management of Asymptomatic and Symptomatic Tumors

DC FieldValueLanguage
dc.contributor.author김긍년-
dc.contributor.author윤도흠-
dc.contributor.author이성-
dc.contributor.author하윤-
dc.date.accessioned2014-12-19T17:50:42Z-
dc.date.available2014-12-19T17:50:42Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92165-
dc.description.abstractPURPOSE: Standard treatment of asymptomatic spinal cord hemangioblastoma in von Hippel-Lindau (VHL) disease has yet to be established. The purpose of this study was to propose guidelines for the treatment of asymptomatic spinal cord hemangioblastomas in VHL disease. MATERIALS AND METHODS: VHL disease patients treated for spinal cord hemangioblastomas between 1999 and 2009 were included. All spinal cord hemangioblastomas were divided into three groups: Group 1, asymptomatic tumors at initial diagnosis followed with serial imaging studies; Group 2, asymptomatic tumors at initial diagnosis that were subsequently resected; and Group 3, symptomatic tumors at initial diagnosis, all of which were resected. RESULTS: We identified 24 spinal cord hemangioblastomas in 12 patients. Groups 1, 2 and 3 comprised 13, 4 and 7 tumors, respectively. Group 1 exhibited a smaller tumor volume (257.1 mm³) and syrinx size (0.8 vertebral columns) than those of Group 2 (1304.5 mm³, 3.3 vertebral columns) and Group 3 (1787.4 mm³, 6.1 vertebral columns). No difference in tumor volume or syrinx size was observed between Groups 2 and 3. Five tumors in Group 1 were resected during follow-up because symptoms had developed or the tumor had significantly grown. Finally, among 17 asymptomatic tumors at the initial diagnosis, nine tumors were resected. Only one tumor of these nine tumors resulted in neurological deficits, while five of seven symptomatic tumors caused neurological deficits. CONCLUSION: Selective resection of asymptomatic tumors before they cause neurological deficits might bring about better outcomes.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHHemangioblastoma/etiology-
dc.subject.MESHHemangioblastoma/pathology*-
dc.subject.MESHHemangioblastoma/surgery*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHvon Hippel-Lindau Disease/complications*-
dc.titleSpinal Cord Hemangioblastomas in von Hippel-Lindau Disease: Management of Asymptomatic and Symptomatic Tumors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorTae Yup Kim-
dc.contributor.googleauthorDo Heum Yoon-
dc.contributor.googleauthorHyun Chul Shin-
dc.contributor.googleauthorKeung Nyun Kim-
dc.contributor.googleauthorSeong Yi-
dc.contributor.googleauthorJae Keun Oh-
dc.contributor.googleauthorYoon Ha-
dc.identifier.doi23074104-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00331-
dc.contributor.localIdA02546-
dc.contributor.localIdA02864-
dc.contributor.localIdA04255-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23074104-
dc.subject.keywordHemangioblastoma-
dc.subject.keywordspinal cord-
dc.subject.keywordtreatment planning-
dc.subject.keywordvon Hippel-Lindau disease-
dc.contributor.alternativeNameKim, Keung Nyun-
dc.contributor.alternativeNameYoon, Do Heum-
dc.contributor.alternativeNameYi, Seong-
dc.contributor.alternativeNameHa, Yoon-
dc.contributor.affiliatedAuthorKim, Keung Nyun-
dc.contributor.affiliatedAuthorYoon, Do Heum-
dc.contributor.affiliatedAuthorYi, Seong-
dc.contributor.affiliatedAuthorHa, Yoon-
dc.citation.volume53-
dc.citation.number6-
dc.citation.startPage1073-
dc.citation.endPage1080-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(6) : 1073-1080, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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