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Estimating average glucose levels from glycated albumin in patients with end-stage renal disease

DC FieldValueLanguage
dc.contributor.author박정탁-
dc.contributor.author오형중-
dc.contributor.author유동은-
dc.contributor.author유태현-
dc.contributor.author최규헌-
dc.contributor.author강신욱-
dc.contributor.author한승혁-
dc.contributor.author김승준-
dc.contributor.author김좌경-
dc.date.accessioned2014-12-19T17:50:14Z-
dc.date.available2014-12-19T17:50:14Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92151-
dc.description.abstractPURPOSE: In patients with diabetic end stage renal disease (ESRD), glycated albumin (GA) reflects recent glycemic control more accurately than glycated hemoglobin (HbA1c). We evaluated the relationship between GA and average blood glucose (AG) level and developed an estimating equation for translating GA values into easier-to-understand AG levels. MATERIALS AND METHODS: A total of 185 ESRD patients, including 154 diabetic and 31 non-diabetic participants, were enrolled (108 hemodialysis, 77 peritoneal dialysis). Patients were asked to perform four-point daily self-monitoring of capillary blood glucose (SMBG) at least three consecutive days each week for four weeks. Serum levels of GA, HbA1c and other biochemical parameters were checked at baseline, as well as at 4 and 8 weeks. RESULTS: Approximately 74.3±7.0 SMBG readings were obtained from each participant and mean AG was 169.1±48.2 mg/dL. The correlation coefficient between serum GA and AG levels (r=0.70, p<0.001) was higher than that of HbA1c and AG (r=0.54, p<0.001). Linear regression analysis yielded the following equation: estimated AG (eAG) (mg/dL)=4.71×GA%+73.35, and with this formula, serum GA levels could be easily translated to eAG levels. Multivariate analysis revealed significant contributions of postprandial hyperglycemia (β=0.25, p=0.03) and serum albumin (β=0.17, p=0.04) in determining serum GA level, independent to other clinical parameters. CONCLUSION: Compared to HbA1c, serum GA levels were better correlated with AG levels. Using the estimating equation, an average blood glucose level of 155-160 mg/dL could be matched to a GA value of 18-19% in patients with ESRD.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlood Glucose/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney Failure, Chronic/blood*-
dc.subject.MESHKidney Failure, Chronic/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHSerum Albumin/metabolism*-
dc.subject.MESHYoung Adult-
dc.titleEstimating average glucose levels from glycated albumin in patients with end-stage renal disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJwa-Kyung Kim-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorDong Eun Yoo-
dc.contributor.googleauthorSeung Jun Kim-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi22477003-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01654-
dc.contributor.localIdA02417-
dc.contributor.localIdA02461-
dc.contributor.localIdA02526-
dc.contributor.localIdA04043-
dc.contributor.localIdA00053-
dc.contributor.localIdA04304-
dc.contributor.localIdA00931-
dc.contributor.localIdA00659-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid22477003-
dc.subject.keywordAverage blood glucose-
dc.subject.keywordend-stage renal disease-
dc.subject.keywordglycated albumin-
dc.subject.keywordself-monitoring blood glucose-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Dong Eun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKim, Seung Jun-
dc.contributor.alternativeNameKim, Jwa Kyung-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Dong Eun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKim, Jwa Kyung-
dc.contributor.affiliatedAuthorKim, Seung Jun-
dc.citation.volume53-
dc.citation.number3-
dc.citation.startPage578-
dc.citation.endPage586-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(3) : 578-586, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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