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Prognostic factors and characteristics of pancreatic neuroendocrine tumors: single center experience
DC Field | Value | Language |
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dc.contributor.author | 오탁근 | - |
dc.contributor.author | 정문재 | - |
dc.contributor.author | 정재복 | - |
dc.contributor.author | 박승우 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 송시영 | - |
dc.date.accessioned | 2014-12-19T17:49:36Z | - |
dc.date.available | 2014-12-19T17:49:36Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92131 | - |
dc.description.abstract | PURPOSE: Pancreatic neuroendocrine tumors (PNET) are a rare subgroup of tumors. For PNETs, the predictive factors for survival and prognosis are not well known. The purpose of our study was to evaluate the predictive factors for survival and disease progression in PNETs. MATERIALS AND METHODS: We retrospectively analyzed 37 patients who were diagnosed with PNET at Severance Hospital between November 2005 and March 2010. Prognostic factors for survival and disease progression were evaluated using the Kaplan-Meier method. RESULTS: The mean age of the patients was 50.0±15.0 years. Eight cases (21.6%) were described as functioning tumors and 29 cases (78.4%) as non-functioning tumors. In univariate analysis of clinical factors, patients with liver metastasis (p=0.002), without resection of primary tumors (p=0.002), or American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) stage III/IV (p=0.002) were more likely to demonstrate shorter overall survival (OS). Patients with bile duct or pancreatic duct invasion (p=0.031), sized-lesions larger than 20 mm (p=0.036), liver metastasis (p=0.020), distant metastasis (p=0.005), lymph node metastasis (p=0.009) or without resection of primary tumors (p=0.020) were more likely to demonstrate shorter progression-free survival (PFS). In multivariate analysis of clinical factors, bile duct or pancreatic duct invasion [p=0.010, hazard ratio (HR)=95.046] and tumor location (non-head of pancreas) (p=0.036, HR=7.381) were confirmed as independent factors for predicting shorter PFS. CONCLUSION: Patients with liver metastasis or without resection of primary tumors were more likely to demonstrate shorter OS. Patients with bile duct or pancreatic duct invasion or tumors located at body or tail of pancreas were more likely to demonstrate shorter PFS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 944~951 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bile Duct Neoplasms/secondary | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/secondary | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neuroendocrine Tumors/complications | - |
dc.subject.MESH | Neuroendocrine Tumors/pathology* | - |
dc.subject.MESH | Pancreatic Neoplasms/complications | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Prognostic factors and characteristics of pancreatic neuroendocrine tumors: single center experience | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Tak Geun Oh | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.contributor.googleauthor | Jeong Yeop Park | - |
dc.contributor.googleauthor | Seung Min Bang | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Jae Bok Chung | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.identifier.doi | 22869477 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02410 | - |
dc.contributor.localId | A03602 | - |
dc.contributor.localId | A03706 | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A02035 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 22869477 | - |
dc.subject.keyword | Pancreatic neuroendocrine tumor | - |
dc.subject.keyword | prognostic factor | - |
dc.subject.keyword | liver metastasis | - |
dc.subject.keyword | bile duct invasion | - |
dc.subject.keyword | pancreatic duct invasion | - |
dc.subject.keyword | location of tumor | - |
dc.contributor.alternativeName | Oh, Tak Geun | - |
dc.contributor.alternativeName | Chung, Moon Jae | - |
dc.contributor.alternativeName | Chung, Jae Bock | - |
dc.contributor.alternativeName | Park, Seung Woo | - |
dc.contributor.alternativeName | Park, Jeong Youp | - |
dc.contributor.alternativeName | Bang, Seung Min | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Oh, Tak Geun | - |
dc.contributor.affiliatedAuthor | Chung, Moon Jae | - |
dc.contributor.affiliatedAuthor | Chung, Jae Bock | - |
dc.contributor.affiliatedAuthor | Park, Seung Woo | - |
dc.contributor.affiliatedAuthor | Park, Jeong Youp | - |
dc.contributor.affiliatedAuthor | Bang, Seung Min | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.citation.volume | 53 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 944 | - |
dc.citation.endPage | 951 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.53(5) : 944-951, 2012 | - |
dc.identifier.rimsid | 29636 | - |
dc.type.rims | ART | - |
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