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Effects of combination therapy with celecoxib and doxycycline on neointimal hyperplasia and inflammatory biomarkers in coronary artery disease patients treated with bare metal stents

DC FieldValueLanguage
dc.contributor.author홍명기-
dc.contributor.author강기운-
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.date.accessioned2014-12-19T17:48:17Z-
dc.date.available2014-12-19T17:48:17Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92091-
dc.description.abstractPURPOSE: Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 play a key role in the pathogenesis of in-stent restenosis. We investigated the effect of a short-term therapy of celecoxib, a COX-2 inhibitor, with or without doxycycline, an MMP inhibitor, after coronary stenting on inflammatory biomarkers and neointimal hyperplasia. MATERIALS AND METHODS: A total of 75 patients (86 lesions) treated with bare metal stents were randomized into three groups: 1) combination therapy (200 mg celecoxib and 20 mg doxycycline, both twice daily), 2) celecoxib (200 mg twice daily) only, and 3) non-therapy control. Celecoxib and doxycycline were administered for 3 weeks after coronary stenting. The primary endpoint was neointimal volume obstruction by intravascular ultrasound (IVUS) at 6 months. The secondary endpoints included clinical outcomes, angiographic data, and changes in blood levels of inflammatory biomarkers. RESULTS: Follow-up IVUS revealed no significant difference in the neointimal volume obstruction among the three treatment groups. There was no difference in cardiac deaths, myocardial infarctions, target lesion revascularization or stent thrombosis among the groups. Blood levels of high-sensitivity C-reactive protein, soluble CD40 ligand, and MMP-9 varied widely 48 hours and 3 weeks after coronary stenting, however, they did not show any significant difference among the groups. CONCLUSION: Our study failed to demonstrate any beneficial effects of the short-term therapy with celecoxib and doxycycline or with celecoxib alone in the suppression of inflammatory biomarkers or in the inhibition of neointimal hyperplasia. Large scale randomized trials are necessary to define the role of anti- inflammatory therapy in the inhibition of neointimal hyperplasia.-
dc.description.statementOfResponsibilityopen-
dc.format.extent68~75-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAngioplasty, Balloon, Coronary-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHCelecoxib-
dc.subject.MESHCoronary Artery Disease/immunology-
dc.subject.MESHCoronary Artery Disease/metabolism-
dc.subject.MESHCoronary Artery Disease/therapy*-
dc.subject.MESHCyclooxygenase 2 Inhibitors/therapeutic use-
dc.subject.MESHDoxycycline/therapeutic use*-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMetals-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeointima/drug therapy*-
dc.subject.MESHNeointima/immunology*-
dc.subject.MESHNeointima/metabolism-
dc.subject.MESHPyrazoles/therapeutic use*-
dc.subject.MESHStents/adverse effects*-
dc.subject.MESHSulfonamides/therapeutic use*-
dc.titleEffects of combination therapy with celecoxib and doxycycline on neointimal hyperplasia and inflammatory biomarkers in coronary artery disease patients treated with bare metal stents-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorKi Woon Kang-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorByung-Keuk Kim-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorYangsoo Jang-
dc.identifier.doi22187234-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04391-
dc.contributor.localIdA00007-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid22187234-
dc.subject.keywordCelecoxib-
dc.subject.keywordcoronary artery disease-
dc.subject.keywordcoronary stent-
dc.subject.keywordneointimal hyperplasia-
dc.subject.keywordinflammation-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.alternativeNameKang, Ki Woon-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKang, Ki Woon-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.citation.volume53-
dc.citation.number1-
dc.citation.startPage68-
dc.citation.endPage75-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(1) : 68-75, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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