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Are clinically insignificant prostate cancers really insignificant among Korean men?
DC Field | Value | Language |
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dc.contributor.author | 박경기 | - |
dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.date.accessioned | 2014-12-19T17:48:06Z | - |
dc.date.available | 2014-12-19T17:48:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92085 | - |
dc.description.abstract | PURPOSE: We aimed to determine whether 12 core-extended biopsies of the prostate could predict insignificant prostate cancer (IPCa) in Koreans reliably enough to recommend active surveillance. MATERIALS AND METHODS: Two hundred and ninety-seven patients who underwent radical prostatectomy after 12 core-extended prostate biopsies were retrospectively reviewed. 38 cases (12.8%) were shown to be IPCa. RESULTS: The average age was 65.2 years, serum PSA was 5.49 ng/dL, and the PSA density was 0.11. The Gleason scores (GS) were 6 (3+3) in 31, 5 (3+2) in 4, and 4 (2+2) in 3. After radical prostatectomy, higher GS was given in 16 (42.1%), whereas lower GS was given in 1 case (2.6%), as compared with the GS obtained from biopsy. 11 (28.9%) had GS of 7 (3+4) and 5 (13.2%) had GS of 7 (4+3). 6 in GS 7 (4+3) and 1 in GS 7 (3+4) showed prostate capsule invasion and 1 in GS 7 (4+3) had seminal vesicle invasion. Prostate capsule invasion was observed in 1 with GS 6 (3+3). The rate of inaccuracy of the contemporary Epstein criteria was 42.1%. Only PSA density was a reliable indicator of clinically IPCa (odds ratio=1.384, 95% CI, 1.103 to 2.091). CONCLUSION: Diagnosis of IPCa from a prostate biopsy underestimated the true nature of prostate cancer in as many as 42.1% of Koreans. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prostate-Specific Antigen/blood | - |
dc.subject.MESH | Prostatectomy | - |
dc.subject.MESH | Prostatic Neoplasms/blood | - |
dc.subject.MESH | Prostatic Neoplasms/diagnosis* | - |
dc.subject.MESH | Prostatic Neoplasms/surgery | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Are clinically insignificant prostate cancers really insignificant among Korean men? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Chan Dong Yeom | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Kyung Kgi Park | - |
dc.contributor.googleauthor | Sang Un Park | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.identifier.doi | 22318824 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A01419 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 22318824 | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | gleason score | - |
dc.subject.keyword | prostate | - |
dc.subject.keyword | clinically insignificant | - |
dc.contributor.alternativeName | Park, Kyung Kgi | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Park, Kyung Kgi | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 358 | - |
dc.citation.endPage | 362 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.53(2) : 358-362, 2012 | - |
dc.identifier.rimsid | 29603 | - |
dc.type.rims | ART | - |
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