Cited 9 times in
Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability
DC Field | Value | Language |
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dc.contributor.author | 노성훈 | - |
dc.contributor.author | 박효진 | - |
dc.contributor.author | 윤영훈 | - |
dc.contributor.author | 이상인 | - |
dc.contributor.author | 김광현 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 장재훈 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 형우진 | - |
dc.contributor.author | 유정환 | - |
dc.date.accessioned | 2014-12-19T17:46:06Z | - |
dc.date.available | 2014-12-19T17:46:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92020 | - |
dc.description.abstract | AIM: To investigate endoscopic and clinicopathologic characteristics of early gastric cancer (EGC) according to microsatellite instability phenotype. METHODS: Data were retrospectively collected from a single tertiary referral center. Of 981 EGC patients surgically treated between December 2003 and October 2007, 73 consecutive EGC patients with two or more microsatellite instability (MSI) mutation [high MSI (MSI-H)] and 146 consecutive EGC patients with one or no MSI mutation (non-MSI-H) were selected. The endoscopic and clinicopathologic features were compared between the MSI-H and non-MSI-H EGC groups. RESULTS: In terms of endoscopic characteristics, MSI-H EGCs more frequently presented with elevated pattern (OR 4.38, 95% CI: 2.40-8.01, P < 0.001), moderate-to-severe atrophy in the surrounding mucosa (OR 1.91, 95% CI: 1.05-3.47, P = 0.033), antral location (OR 3.99, 95% CI: 2.12-7.52, P < 0.001) and synchronous lesions, compared to non-MSI-H EGCs (OR 2.65, 95% CI: 1.16-6.07, P = 0.021). Other significant clinicopathologic characteristics of MSI-H EGC included predominance of female sex (OR 2.77, 95% CI: 1.53-4.99, P < 0.001), older age (> 70 years) (OR 3.30, 95% CI: 1.57-6.92, P = 0.002), better histologic differentiation (OR 2.35, 95% CI: 1.27-4.34, P = 0.007), intestinal type by Lauren classification (OR 2.34, 95% CI: 1.15-4.76, P = 0.019), absence of a signet ring cell component (OR 2.44, 95% CI: 1.02-5.86, P = 0.046), presence of mucinous component (OR 5.06, 95% CI: 1.27-20.17, P = 0.022), moderate-to-severe lymphoid stromal reaction (OR 3.95, 95% CI: 1.59-9.80, P = 0.003), and co-existing underlying adenoma (OR 2.66, 95% CI: 1.43-4.95, P = 0.002). CONCLUSION: MSI-H EGC is associated with unique endoscopic and clinicopathologic characteristics including frequent presentation in protruded type, co-existing underlying adenoma, and synchronous lesions. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoma/pathology | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrophy | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Early Detection of Cancer | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastric Mucosa/pathology* | - |
dc.subject.MESH | Gastroscopy* | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metaplasia | - |
dc.subject.MESH | Microsatellite Instability* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.title | Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Jaehoon Jahng | - |
dc.contributor.googleauthor | Young Hoon Youn | - |
dc.contributor.googleauthor | Kwang Hyun Kim | - |
dc.contributor.googleauthor | Junghwan Yu | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Woo Jin Hyung | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Hogeun Kim | - |
dc.contributor.googleauthor | Hyojin Park | - |
dc.contributor.googleauthor | Sang In Lee | - |
dc.identifier.doi | 10.3748/wjg.v18.i27.3571 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01774 | - |
dc.contributor.localId | A02506 | - |
dc.contributor.localId | A02583 | - |
dc.contributor.localId | A02828 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A03466 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A04382 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 22826622 | - |
dc.subject.keyword | Advanced gastric cancer | - |
dc.subject.keyword | Early gastric cancer | - |
dc.subject.keyword | Endoscopic characteristic | - |
dc.subject.keyword | Microsatellite instability | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.alternativeName | You, Jung Whan | - |
dc.contributor.alternativeName | Youn, Young Hoon | - |
dc.contributor.alternativeName | Lee, Sang In | - |
dc.contributor.alternativeName | Kim, Kwang Hyun | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Jahng, Jae Hoon | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Youn, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Sang In | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Jahng, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.citation.volume | 18 | - |
dc.citation.number | 27 | - |
dc.citation.startPage | 3571 | - |
dc.citation.endPage | 3577 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.18(27) : 3571-3577, 2012 | - |
dc.identifier.rimsid | 30076 | - |
dc.type.rims | ART | - |
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