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Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability

DC FieldValueLanguage
dc.contributor.author노성훈-
dc.contributor.author박효진-
dc.contributor.author윤영훈-
dc.contributor.author이상인-
dc.contributor.author김광현-
dc.contributor.author이용찬-
dc.contributor.author김현기-
dc.contributor.author장재훈-
dc.contributor.author김호근-
dc.contributor.author형우진-
dc.contributor.author유정환-
dc.date.accessioned2014-12-19T17:46:06Z-
dc.date.available2014-12-19T17:46:06Z-
dc.date.issued2012-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92020-
dc.description.abstractAIM: To investigate endoscopic and clinicopathologic characteristics of early gastric cancer (EGC) according to microsatellite instability phenotype. METHODS: Data were retrospectively collected from a single tertiary referral center. Of 981 EGC patients surgically treated between December 2003 and October 2007, 73 consecutive EGC patients with two or more microsatellite instability (MSI) mutation [high MSI (MSI-H)] and 146 consecutive EGC patients with one or no MSI mutation (non-MSI-H) were selected. The endoscopic and clinicopathologic features were compared between the MSI-H and non-MSI-H EGC groups. RESULTS: In terms of endoscopic characteristics, MSI-H EGCs more frequently presented with elevated pattern (OR 4.38, 95% CI: 2.40-8.01, P < 0.001), moderate-to-severe atrophy in the surrounding mucosa (OR 1.91, 95% CI: 1.05-3.47, P = 0.033), antral location (OR 3.99, 95% CI: 2.12-7.52, P < 0.001) and synchronous lesions, compared to non-MSI-H EGCs (OR 2.65, 95% CI: 1.16-6.07, P = 0.021). Other significant clinicopathologic characteristics of MSI-H EGC included predominance of female sex (OR 2.77, 95% CI: 1.53-4.99, P < 0.001), older age (> 70 years) (OR 3.30, 95% CI: 1.57-6.92, P = 0.002), better histologic differentiation (OR 2.35, 95% CI: 1.27-4.34, P = 0.007), intestinal type by Lauren classification (OR 2.34, 95% CI: 1.15-4.76, P = 0.019), absence of a signet ring cell component (OR 2.44, 95% CI: 1.02-5.86, P = 0.046), presence of mucinous component (OR 5.06, 95% CI: 1.27-20.17, P = 0.022), moderate-to-severe lymphoid stromal reaction (OR 3.95, 95% CI: 1.59-9.80, P = 0.003), and co-existing underlying adenoma (OR 2.66, 95% CI: 1.43-4.95, P = 0.002). CONCLUSION: MSI-H EGC is associated with unique endoscopic and clinicopathologic characteristics including frequent presentation in protruded type, co-existing underlying adenoma, and synchronous lesions.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfWorld Journal of Gastroenterology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenoma/pathology-
dc.subject.MESHAged-
dc.subject.MESHAtrophy-
dc.subject.MESHBiopsy-
dc.subject.MESHCell Differentiation-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHEarly Detection of Cancer-
dc.subject.MESHFemale-
dc.subject.MESHGastric Mucosa/pathology*-
dc.subject.MESHGastroscopy*-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMetaplasia-
dc.subject.MESHMicrosatellite Instability*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation*-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPhenotype-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.titleEndoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJaehoon Jahng-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorKwang Hyun Kim-
dc.contributor.googleauthorJunghwan Yu-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorHogeun Kim-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorSang In Lee-
dc.identifier.doi22826622-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01281-
dc.contributor.localIdA01774-
dc.contributor.localIdA02506-
dc.contributor.localIdA02583-
dc.contributor.localIdA02828-
dc.contributor.localIdA02988-
dc.contributor.localIdA01108-
dc.contributor.localIdA03466-
dc.contributor.localIdA01183-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ02795-
dc.identifier.pmid22826622-
dc.subject.keywordAdvanced gastric cancer-
dc.subject.keywordEarly gastric cancer-
dc.subject.keywordEndoscopic characteristic-
dc.subject.keywordMicrosatellite instability-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameYou, Jung Whan-
dc.contributor.alternativeNameYoun, Young Hoon-
dc.contributor.alternativeNameLee, Sang In-
dc.contributor.alternativeNameKim, Kwang Hyun-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameJahng, Jae Hoon-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorYoun, Young Hoon-
dc.contributor.affiliatedAuthorLee, Sang In-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorJahng, Jae Hoon-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.citation.volume18-
dc.citation.number27-
dc.citation.startPage3571-
dc.citation.endPage3577-
dc.identifier.bibliographicCitationWorld Journal of Gastroenterology, Vol.18(27) : 3571-3577, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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