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Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor

Authors
 Yoonkyung Do  ;  Arnaud M. Didierlaurent  ;  Seongho Ryu  ;  Hyein Koh  ;  Chae Gyu Park  ;  Steven Park  ;  David S. Perlin  ;  Bradford S. Powell  ;  Ralph M. Steinman 
Citation
 Vaccine, Vol.30(45) : 6359-6367, 2012 
Journal Title
 Vaccine 
ISSN
 0264-410X 
Issue Date
2012
Abstract
It is of great interest to develop a pneumonic plague vaccine that would induce combined humoral and cellular immunity in the lung. Here we investigate a novel approach based on targeting of dendritic cells using the DEC-205/CD205 receptor (DEC) via the intranasal route as way to improve mucosal cellular immunity to the vaccine. Intranasal administration of Yersinia pestis LcrV (V) protein fused to anti-DEC antibody together with poly IC as an adjuvant induced high frequencies of IFN-γ secreting CD4+ T cells in the airway and lung as well as pulmonary IgG and IgA antibodies. Anti-DEC:LcrV was more efficient to induce IFN-γ/TNF-α/IL-2 secreting polyfunctional CD4+ T cells when compared to non-targeted soluble protein vaccine. In addition, the intranasal route of immunization with anti-DEC:LcrV was associated with improved survival upon pulmonary challenge with the virulent CO92 Y. pestis. Taken together, these data indicate that targeting dendritic cells via the mucosal route is a potential new avenue for the development of a mucosal vaccine against pneumonic plague.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92003
DOI
10.1016/j.vaccine.2012.08.051
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
박채규(Park, Chae Gyu)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0264410X12012443
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