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Antiviral prophylaxis versus preemptive therapy to prevent cytomegalovirus infection and related death in liver transplantation: a retrospective study with propensity score matching

DC Field Value Language
dc.contributor.author김명수-
dc.date.accessioned2014-12-19T17:44:27Z-
dc.date.available2014-12-19T17:44:27Z-
dc.date.issued2012-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91967-
dc.description.abstractBACKGROUND: Cytomegalovirus (CMV), the most significant viral infection in liver transplant recipients, is addressed by 2 methods: Preemptive therapy (PT) or universal prophylaxis (UP). METHODS: We analyzed medical records including at least 1 year follow-up of patients who underwent liver transplantation from 2006 to 2009 in 3 tertiary hospitals. PT was used in 2 hospitals (PT group), whereas UP with valganciclovir for 3 months was adopted in the other hospital (UP group). The 2 groups were matched using propensity scoring by perioperative variables. We performed a 1:1 comparison of the efficacy of UP and PT. RESULTS: We analyzed 634 liver transplant patients, including 562 matched subjects. Baseline characteristics and underlying liver status were comparable. CMV immunoglobulin G of recipients was positive in 98.9% of the PT group and 99.3% of the UP group. CMV viremia episodes that required administration of an antiviral agent occurred in 26 (9.3%) PT and 37 (13.2%) UP subjects (P = .18). CMV-related mortalities were similar (0.7% vs 1.8%; P = .45), but all-cause mortality was higher in the PT group (18.5% vs 13.2%; P = .08). CONCLUSION: The efficacy of PT was similar to UP to prevent CMV disease and related mortality among a group at moderate risk for CMV infection.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTRANSPLANTATION PROCEEDINGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntiviral Agents/administration & dosage*-
dc.subject.MESHCytomegalovirus/isolation & purification-
dc.subject.MESHCytomegalovirus Infections/mortality-
dc.subject.MESHCytomegalovirus Infections/prevention & control*-
dc.subject.MESHFemale-
dc.subject.MESHGanciclovir/administration & dosage-
dc.subject.MESHGanciclovir/analogs & derivatives*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Transplantation/adverse effects*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.titleAntiviral prophylaxis versus preemptive therapy to prevent cytomegalovirus infection and related death in liver transplantation: a retrospective study with propensity score matching-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorS.I. Kim-
dc.contributor.googleauthorC.J. Kim-
dc.contributor.googleauthorY.J. Kim-
dc.contributor.googleauthorH. Son-
dc.contributor.googleauthorY.E. Kim-
dc.contributor.googleauthorM.S. Kim-
dc.contributor.googleauthorS. Hwang-
dc.contributor.googleauthorJ.I. Kim-
dc.contributor.googleauthorY.K. You-
dc.contributor.googleauthorD.G. Kim-
dc.contributor.googleauthorM.W. Kang-
dc.identifier.doi22483496-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid22483496-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0041134512001078-
dc.subject.keywordAdult-
dc.subject.keywordAntiviral Agents/administration & dosage*-
dc.subject.keywordCytomegalovirus/isolation & purification-
dc.subject.keywordCytomegalovirus Infections/mortality-
dc.subject.keywordCytomegalovirus Infections/prevention & control*-
dc.subject.keywordFemale-
dc.subject.keywordGanciclovir/administration & dosage-
dc.subject.keywordGanciclovir/analogs & derivatives*-
dc.subject.keywordHumans-
dc.subject.keywordLiver Transplantation/adverse effects*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordRetrospective Studies-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.citation.volume44-
dc.citation.number3-
dc.citation.startPage787-
dc.citation.endPage790-
dc.identifier.bibliographicCitationTRANSPLANTATION PROCEEDINGS, Vol.44(3) : 787-790, 2012-
dc.identifier.rimsid30036-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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