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C4d deposition and multilayering of peritubular capillary basement membrane in posttransplantation membranous nephropathy indicate its association with antibody-mediated injury
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 정현주 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김순일 | - |
dc.date.accessioned | 2014-12-19T17:44:14Z | - |
dc.date.available | 2014-12-19T17:44:14Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91960 | - |
dc.description.abstract | Membranous nephropathy (MN) may develop as recurrence or de novo after transplantation. Recently, autoimmune or alloimmune responses to unspecified glomerular antigens have been considered as a pathogenetic mechanism. To explore the relationship between antibody-mediated injury and posttransplantation MN, we tested C4d positivity using polyclonal antibody in renal allograft biopsy samples diagnosed as posttransplantation MN. A total of 19 cases (16 males and 3 females), including 2 recurrent and 7 de novo forms, were the subject of the study. On light microscopy, stage II was the most common (n = 9). In addition to glomerular capillary immunoglobulin (Ig)G deposits, all but 2 cases having only sclerotic glomeruli were C4d-positive in glomerular capillary walls. Twelve cases were also positive in cortical peritubular capillaries (PTCs): diffuse in 8 cases and focal in 4 cases. Two of 3 cases associated with acute rejection and 3 of 4 cases associated with chronic rejection were PTC C4d-positive. The frequency of C4d positivity in PTCs was significantly higher than that of posttransplantation IgA nephropathy (P = .028). In conclusion, a higher frequency of PTC C4d positivity suggests an involvement of chronic antibody-mediated injury in the evolution of posttransplantation MN. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | TRANSPLANTATION PROCEEDINGS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Autoantibodies/immunology* | - |
dc.subject.MESH | Basement Membrane/metabolism* | - |
dc.subject.MESH | Complement C4b/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerulonephritis, Membranous/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kidney Transplantation/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Peptide Fragments/metabolism* | - |
dc.title | C4d deposition and multilayering of peritubular capillary basement membrane in posttransplantation membranous nephropathy indicate its association with antibody-mediated injury | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | B.J. Lim | - |
dc.contributor.googleauthor | M.S. Kim | - |
dc.contributor.googleauthor | Y.S. Kim | - |
dc.contributor.googleauthor | S.I. Kim | - |
dc.contributor.googleauthor | H.J. Jeong | - |
dc.identifier.doi | 22483452 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A03771 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J02755 | - |
dc.identifier.eissn | 1873-2623 | - |
dc.identifier.pmid | 22483452 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0041134511017143 | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Autoantibodies/immunology* | - |
dc.subject.keyword | Basement Membrane/metabolism* | - |
dc.subject.keyword | Complement C4b/metabolism* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Glomerulonephritis, Membranous/immunology* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Kidney Transplantation/immunology* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Peptide Fragments/metabolism* | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Jeong, Hyeon Joo | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.citation.volume | 44 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 619 | - |
dc.citation.endPage | 620 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, Vol.44(3) : 619-620, 2012 | - |
dc.identifier.rimsid | 30030 | - |
dc.type.rims | ART | - |
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