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Renal transplantation in sensitized recipients with positive luminex and negative CDC (complement-dependent cytotoxicity) crossmatches

DC FieldValueLanguage
dc.contributor.author김명수-
dc.contributor.author김범석-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author주동진-
dc.contributor.author주만기-
dc.contributor.author허규하-
dc.date.accessioned2014-12-19T17:43:46Z-
dc.date.available2014-12-19T17:43:46Z-
dc.date.issued2012-
dc.identifier.issn0934-0874-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91945-
dc.description.abstractRecently, Luminex-crossmatch (LumXm) was introduced. The aim of this study was to evaluate clinical outcomes in sensitized recipients with a positive Luminex-crossmatch (LumXm (+)) and a negative complement-dependent cytotoxicity crossmatch (CDCXm (-)) after renal transplantation. Fifty-five renal transplant recipients with a CDCXm (-) and PRA class I or II ≥20% were enrolled in this study between February 2008 and December 2010 at Severance Hospital. Eighteen patients displayed LumXm (+) defined as LumXm positive class I or II and 37 patients displayed LumXm (-). Mean duration of follow-up was 18.9 ± 8.3 months. During this period, no patient death or graft loss occurred. The incidence of biopsy-proven or clinically presumed rejection was higher in the LumXm (+) group (n = 12, 66.7%) than in the LumXm (-) group (n = 6, 18.2%) (P = 0.001). All biopsy-proven acute rejections (n = 12) were diagnosed as acute cellular rejection. No significant difference in mean serum creatinine level or eGFR was observed between the groups at 18 months post-transplantation. The short-term outcome of renal transplantation in sensitized patients with a LumXm (+) and a CDCXm (-) may be considered to be acceptable. However, patients with a LumXm (+) have a substantially higher immunological risk for the development of acute cellular rejection.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTRANSPLANT INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHComplement System Proteins/immunology*-
dc.subject.MESHCytotoxicity Tests, Immunologic/methods-
dc.subject.MESHCytotoxicity, Immunologic*-
dc.subject.MESHFemale-
dc.subject.MESHGraft Rejection/immunology*-
dc.subject.MESHHLA Antigens/immunology-
dc.subject.MESHHumans-
dc.subject.MESHKidney Transplantation/immunology*-
dc.subject.MESHKidney Transplantation/physiology-
dc.subject.MESHLiving Donors-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHT-Lymphocytes/immunology-
dc.titleRenal transplantation in sensitized recipients with positive luminex and negative CDC (complement-dependent cytotoxicity) crossmatches-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorKyu Ha Huh-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorHae Jin Kim-
dc.contributor.googleauthorDong Jin Joo-
dc.contributor.googleauthorBeom Seok Kim-
dc.contributor.googleauthorMan Ki Ju-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.identifier.doi22897830-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00488-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA03948-
dc.contributor.localIdA03949-
dc.contributor.localIdA04344-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ02753-
dc.identifier.eissn1432-2277-
dc.identifier.pmid22897830-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1432-2277.2012.01543.x/abstract-
dc.subject.keywordCDC crossmatch-
dc.subject.keywordLuminex-crossmatch-
dc.subject.keywordrenaltransplantation.-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.alternativeNameJoo, Man Ki-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorJoo, Man Ki-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.citation.volume25-
dc.citation.number11-
dc.citation.startPage1131-
dc.citation.endPage1137-
dc.identifier.bibliographicCitationTRANSPLANT INTERNATIONAL, Vol.25(11) : 1131-1137, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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