Cited 10 times in
Matrix metalloproteinase-2, -9, -12, and tissue inhibitor of metalloproteinase 2 gene polymorphisms and cutaneous expressions in patients with Behçet's disease
DC Field | Value | Language |
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dc.contributor.author | 방동식 | - |
dc.date.accessioned | 2014-12-19T17:43:19Z | - |
dc.date.available | 2014-12-19T17:43:19Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0001-2815 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91930 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) induce leukocyte migration into inflammation sites that lead to either promotion or repression of inflammation by activating or inactivating cytokines. An increased level of MMP-9 and a decreased level of MMP-2 have been observed in Behçet's disease (BD). This study was performed to analyze the relationship between MMP-2, -9, -12 and the tissue inhibitor of metalloproteinase-2 (TIMP-2) promoter polymorphisms in developing BD. The expression of MMP-2 and -9 was also evaluated in the skin of BD. The MMPs and TIMP-2 polymorphisms were confirmed by using polymerase chain reaction-restriction fragment length polymorphism in 251 BD and 312 controls. Cutaneous expression of MMP-2 and -9 in 17 BD patients with erythema nodosum (EN) or EN-like lesion was compared with 14 patients with idiopathic EN by immunohistochemical stains. The frequency of MMP-2-1575*G/*G and MMP-2-735*C/*C genotypes was shown to be lower in BD, whereas MMP-9-1562*C/*C was significantly higher in BD compared with the controls. The frequency of common haplotype MMP-2-1575*G -735*C was significantly lower in BD patients than in controls (P = 0.0046, permutation P = 0.009). No significant differences were observed between BD and controls in the allele and genotype frequencies of MMP-12-82A>G or TIMP-2-418G>C polymorphisms. The tissue expression of MMP-2, shown by immunohistochemistry, was significantly lower in BD compared with the controls. However, the expression of MMP-9 was significantly higher in BD. These results suggest that MMP-2 and -9 could each modulate the development of BD in opposite directions. Major genotypes of the MMP-2-1575*G/*G and MMP-2-735*C/*C and the common MMP-2-1575*G -735*C haplotype may provide some protection against development of BD, while MMP-9-1562*C/*C may promote the disease. The reciprocal expression of MMP-2 and -9 in the skin tissue of BD was also confirmed. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | TISSUE ANTIGENS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Matrix metalloproteinase-2, -9, -12, and tissue inhibitor of metalloproteinase 2 gene polymorphisms and cutaneous expressions in patients with Behçet's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | K. S. Park | - |
dc.contributor.googleauthor | Y. Min | - |
dc.contributor.googleauthor | S. R. Park | - |
dc.contributor.googleauthor | E. H. Kim | - |
dc.contributor.googleauthor | D. J. Lee | - |
dc.contributor.googleauthor | D. Bang | - |
dc.contributor.googleauthor | E.-S. Lee | - |
dc.identifier.doi | 10.1111/j.1399-0039.2012.01863.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01784 | - |
dc.relation.journalcode | J02731 | - |
dc.identifier.eissn | 1399-0039 | - |
dc.identifier.pmid | Behc¸et’s disease ; matrixmetalloproteinase-2, -9, -12 ; tissue inhibitorsof metalloproteinase-2 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0039.2012.01863.x/abstract | - |
dc.subject.keyword | Behc¸et’s disease | - |
dc.subject.keyword | matrixmetalloproteinase-2, -9, -12 | - |
dc.subject.keyword | tissue inhibitorsof metalloproteinase-2 | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.affiliatedAuthor | Bang, Dong Sik | - |
dc.citation.volume | 79 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 333 | - |
dc.citation.endPage | 339 | - |
dc.identifier.bibliographicCitation | TISSUE ANTIGENS , Vol.79(5) : 333-339, 2012 | - |
dc.identifier.rimsid | 30012 | - |
dc.type.rims | ART | - |
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