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Measurement of plasma sTREM-1 in patients with severe sepsis receiving early goal-directed therapy and evaluation of its usefulness

DC FieldValueLanguage
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.contributor.author구남수-
dc.contributor.author김준명-
dc.contributor.author김창오-
dc.contributor.author김혜원-
dc.contributor.author송영구-
dc.contributor.author정수진-
dc.date.accessioned2014-12-19T17:40:12Z-
dc.date.available2014-12-19T17:40:12Z-
dc.date.issued2012-
dc.identifier.issn1073-2322-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91848-
dc.description.abstractThe plasma level of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) has been shown to be helpful in identifying critically ill patients with infection. However, it remains unknown whether it can be used to predict prognosis in patients with severe sepsis. This study investigated whether various inflammatory mediators, including sTREM-1, could be used as reliable markers to predict the prognosis of patients receiving early goal-directed therapy (EGDT). We prospectively enrolled patients 18 years or older with severe sepsis from April 2009 to May 2010 at a 2,000-bed university hospital. Patients were eligible if the initial resuscitation according to EGDT protocol was immediately performed at the emergency department. Plasma sTREM-1, C-reactive protein, and procalcitonin concentrations were measured on days 0, 3, 7, and 14. Soluble TREM-1 concentrations were significantly higher at admission and pre-EGDT in nonsurvivors (n = 16) than in survivors (n = 47) (514.1 pg/mL [interquartile range, 412.7-1,749.5 pg/mL] vs. 182.4 pg/mL [interquartile range, 54.3-327.0 pg/mL]; P = 0.001). Procalcitonin and C-reactive protein levels did not significantly differ, whereas central venous oxygen saturation and lactate levels at admission were significantly different between the two groups. The only sTREM-1 level remained significantly higher in nonsurvivors until death. On multivariate regression analysis, log(sTREM-1) (P = 0.028), central venous oxygen saturation (P = 0.022), and Simplified Acute Physiology Score II (P = 0.048) values at admission were independently significant. These results suggest that plasma sTREM-1 level at admission could be used as a marker to identify patients with a poor prognosis despite complete initial resuscitation in severe sepsis.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfSHOCK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMeasurement of plasma sTREM-1 in patients with severe sepsis receiving early goal-directed therapy and evaluation of its usefulness-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJeong, Su Jin-
dc.contributor.googleauthorSong, Young Goo-
dc.contributor.googleauthorKim, Chang Oh-
dc.contributor.googleauthorKim, Hye Won-
dc.contributor.googleauthorKu, Nam Su-
dc.contributor.googleauthorHan, Sang Hoon-
dc.contributor.googleauthorChoi, Jun Yong-
dc.contributor.googleauthorKim, June Myung-
dc.identifier.doi10.1097/SHK.0b013e318250da40-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.contributor.localIdA00189-
dc.contributor.localIdA00953-
dc.contributor.localIdA01044-
dc.contributor.localIdA01176-
dc.contributor.localIdA02037-
dc.contributor.localIdA03638-
dc.relation.journalcodeJ02658-
dc.identifier.eissn1540-0514-
dc.identifier.pmidSoluble triggering receptor expressed on myeloid cells 1 ; procalcitonin ; central venous oxygen saturation ; severe sepsis ; early-goal directed therapy ; prognosis-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00024382-201206000-00003&LSLINK=80&D=ovft-
dc.subject.keywordSoluble triggering receptor expressed on myeloid cells 1-
dc.subject.keywordprocalcitonin-
dc.subject.keywordcentral venous oxygen saturation-
dc.subject.keywordsevere sepsis-
dc.subject.keywordearly-goal directed therapy-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameKim, Hye Won-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorKim, Hye Won-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.citation.volume37-
dc.citation.number6-
dc.citation.startPage574-
dc.citation.endPage578-
dc.identifier.bibliographicCitationSHOCK, Vol.37(6) : 574-578, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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