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Elevated interleukin-32 expression in granulomatosis with polyangiitis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.date.accessioned | 2014-12-19T17:39:05Z | - |
dc.date.available | 2014-12-19T17:39:05Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0080-2727 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91812 | - |
dc.description.abstract | OBJECTIVE: To evaluate the role of IL-32 in granulomatosis with polyangiitis (GPA) patients and the relationship between IL-32 and disease activity, as PR3 has the ability to bind and activate IL-32, which has been described as a novel cytokine that induces inflammatory cytokines. METHODS: We investigated the level of IL-32, PR3, TNF-α and IL-6 in GPA patients by using ELISA. Northern blot was used to analyse the level of IL-32 mRNA in leucocytes of GPA patients. The intracellular colocalization of IL-32 and PR3 in leucocytes was examined by IF staining. RESULTS: We observed that IL-32 and PR3 levels in GPA patients were increased significantly when compared with normal individuals and each was tightly associated (P < 0.001). Northern blot analysis revealed that the mRNA level of IL-32 was prominently elevated in leucocytes of GPA patients. The intracellular colocalization of IL-32 and PR3 in leucocytes from GPA patients vs normal individuals was verified by IF staining. CONCLUSION: IL-32 level was elevated in GPA patients but its level was changed by treatment response. IL-32 could be an index in GPA and play a role in the aetiology of GPA. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blotting, Northern | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Granulomatosis with Polyangiitis/etiology* | - |
dc.subject.MESH | Granulomatosis with Polyangiitis/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-6/metabolism | - |
dc.subject.MESH | Interleukins/metabolism | - |
dc.subject.MESH | Interleukins/physiology* | - |
dc.subject.MESH | Leukocytes/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myeloblastin/metabolism | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.subject.MESH | Vasculitis/etiology | - |
dc.subject.MESH | Vasculitis/metabolism | - |
dc.title | Elevated interleukin-32 expression in granulomatosis with polyangiitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Suyoung Bae | - |
dc.contributor.googleauthor | Yong-Gil Kim | - |
dc.contributor.googleauthor | Jida Choi | - |
dc.contributor.googleauthor | Jaewoo Hong | - |
dc.contributor.googleauthor | Siyoung Lee | - |
dc.contributor.googleauthor | Taebong Kang | - |
dc.contributor.googleauthor | Hyunjhung Jeon | - |
dc.contributor.googleauthor | Kwangwon Hong | - |
dc.contributor.googleauthor | Eusom Kim | - |
dc.contributor.googleauthor | Areum Kwak | - |
dc.contributor.googleauthor | Chang-Keun Lee | - |
dc.contributor.googleauthor | Bin Yoo | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Eun Young Song | - |
dc.contributor.googleauthor | Soohyun Kim | - |
dc.identifier.doi | 22850185 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01579 | - |
dc.relation.journalcode | J02624 | - |
dc.identifier.pmid | 22850185 | - |
dc.identifier.url | http://rheumatology.oxfordjournals.org/content/51/11/1979.long | - |
dc.subject.keyword | cytokine | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | IL-32 | - |
dc.subject.keyword | neutrophil PR3 | - |
dc.subject.keyword | granulomatosis with polyangiitis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.citation.volume | 51 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1979 | - |
dc.citation.endPage | 1988 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY , Vol.51(11) : 1979-1988, 2012 | - |
dc.identifier.rimsid | 31213 | - |
dc.type.rims | ART | - |
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