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C-phycocyanin attenuates cisplatin-induced nephrotoxicity in mice

Authors
 Beom Jin Lim  ;  Jin Young Jeong  ;  Yoon-Kyung Chang  ;  Ki-Ryang Na  ;  Kang Wook Lee  ;  Young-Tai Shin  ;  Dae Eun Choi 
Citation
 RENAL FAILURE, Vol.34(7) : 892-900, 2012 
Journal Title
 RENAL FAILURE 
ISSN
 0886-022X 
Issue Date
2012
MeSH
Animals ; Antineoplastic Agents/adverse effects* ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Line ; Cell Survival ; Cells, Cultured ; Cisplatin/adverse effects* ; In Situ Nick-End Labeling ; Kidney/pathology ; Kidney Diseases/chemically induced* ; Kidney Diseases/enzymology ; Kidney Diseases/pathology ; Kidney Diseases/prevention & control ; Kidney Function Tests ; Male ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinases/metabolism ; Phycocyanin/therapeutic use*
Keywords
C-phycocyanin ; apoptosis ; cisplatin-induced nephrotoxicity
Abstract
Although cisplatin is a highly effective antineoplastic agent, nephrotoxicity is its major clinical problem. Recently, it was reported that Spirulina, a blue-green algae, has potent antioxidant properties. The aim of this study was to establish the possible protective role of C-phycocyanin (PC), one of the active ingredients of Spirulina, against cisplatin-induced nephrotoxicity. This study was carried out using human kidney-2 (HK-2) cells and male C57BL6 mice. Cells and mice were divided into four groups; untreated control group, PC-treated control group, cisplatin-treated group, and PC plus cisplatin-treated group. The molecular, functional, and structural parameters were measured. PC significantly attenuated blood urea nitrogen, serum creatinine, renal histological damages, and apoptotic cell death in cisplatin-treated mice. The cisplatin-induced cell death was significantly attenuated in cells pretreated with PC. PC also significantly attenuated the elevation of p-ERK, p-JNK, and p-p38 induced by cisplatin treatment. The expression of Bax, caspase-9, and caspase-3 in cisplatin-treated cells were also decreased by PC treatment. In conclusion, PC ameliorates cisplatin-induced nephrotoxicity and, at least in part, suppression of p-ERK, p-JNK, p-p38, Bax, caspase-9, and caspase-3 may be involved in this mechanism.
Full Text
http://informahealthcare.com/doi/abs/10.3109/0886022X.2012.690925
DOI
22681485
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91788
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