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C-phycocyanin attenuates cisplatin-induced nephrotoxicity in mice

Authors
 Beom Jin Lim  ;  Jin Young Jeong  ;  Yoon-Kyung Chang  ;  Ki-Ryang Na  ;  Kang Wook Lee  ;  Young-Tai Shin  ;  Dae Eun Choi 
Citation
 Renal Failure, Vol.34(7) : 892-900, 2012 
Journal Title
 Renal Failure 
ISSN
 0886-022X 
Issue Date
2012
Abstract
Although cisplatin is a highly effective antineoplastic agent, nephrotoxicity is its major clinical problem. Recently, it was reported that Spirulina, a blue-green algae, has potent antioxidant properties. The aim of this study was to establish the possible protective role of C-phycocyanin (PC), one of the active ingredients of Spirulina, against cisplatin-induced nephrotoxicity. This study was carried out using human kidney-2 (HK-2) cells and male C57BL6 mice. Cells and mice were divided into four groups; untreated control group, PC-treated control group, cisplatin-treated group, and PC plus cisplatin-treated group. The molecular, functional, and structural parameters were measured. PC significantly attenuated blood urea nitrogen, serum creatinine, renal histological damages, and apoptotic cell death in cisplatin-treated mice. The cisplatin-induced cell death was significantly attenuated in cells pretreated with PC. PC also significantly attenuated the elevation of p-ERK, p-JNK, and p-p38 induced by cisplatin treatment. The expression of Bax, caspase-9, and caspase-3 in cisplatin-treated cells were also decreased by PC treatment. In conclusion, PC ameliorates cisplatin-induced nephrotoxicity and, at least in part, suppression of p-ERK, p-JNK, p-p38, Bax, caspase-9, and caspase-3 may be involved in this mechanism.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91788
DOI
10.3109/0886022X.2012.690925
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
임범진(Lim, Beom Jin)
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Full Text
http://informahealthcare.com/doi/abs/10.3109/0886022X.2012.690925
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