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Hippocampus and nucleus accumbens activity during neutral word recognition related to trait physical anhedonia in patients with schizophrenia: an fMRI study

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dc.contributor.author강지인-
dc.contributor.author김재진-
dc.contributor.author박해정-
dc.contributor.author이정석-
dc.date.accessioned2014-12-19T17:37:31Z-
dc.date.available2014-12-19T17:37:31Z-
dc.date.issued2012-
dc.identifier.issn0165-1781-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91761-
dc.description.abstractEmotional memory dysfunction may be associated with anhedonia in schizophrenia. This study aimed to investigate the neurobiological basis of emotional memory and its relationship with anhedonia in schizophrenia specifically in emotional memory relate brain regions of interest (ROIs) including the amygdala, hippocampus, nucleus accumbens, and ventromedial prefrontal cortex. Fourteen patients with schizophrenia and 16 healthy subjects performed a word-image associative encoding task, during which a neutral word was presented with a positive, neutral, or control image. Subjects underwent functional magnetic resonance imaging while performing the recognition task. Correlation analyses were performed between the percent signal change (PSC) in the ROIs and the anhedonia scores. We found no group differences in recognition accuracy and reaction time. The PSC of the hippocampus in the positive and neutral conditions, and the PSC in the nucleus accumbens in the control condition, appeared to be negatively correlated with the Physical Anhedonia Scale (PAS) scores in patients with schizophrenia, while significant correlations with the PAS scores were not observed in healthy subjects. This study provides further evidences of the role of the hippocampus and nucleus accumbens in trait physical anhedonia and possible associations between emotional memory deficit and trait physical anhedonia in patients with schizophrenia.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPSYCHIATRY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnhedonia*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHEmotions-
dc.subject.MESHFemale-
dc.subject.MESHFunctional Neuroimaging-
dc.subject.MESHHippocampus/physiopathology*-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHNucleus Accumbens/physiopathology*-
dc.subject.MESHReaction Time-
dc.subject.MESHRecognition (Psychology)-
dc.subject.MESHSchizophrenia/physiopathology*-
dc.titleHippocampus and nucleus accumbens activity during neutral word recognition related to trait physical anhedonia in patients with schizophrenia: an fMRI study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학)-
dc.contributor.googleauthorJung Suk Lee-
dc.contributor.googleauthorJi Won Chun-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorDong-Il Kang-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorJae-Jin Kim-
dc.identifier.doi22867952-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00084-
dc.contributor.localIdA00870-
dc.contributor.localIdA01730-
dc.contributor.localIdA03105-
dc.relation.journalcodeJ02571-
dc.identifier.eissn1872-7123-
dc.identifier.pmid22867952-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0925492711003118-
dc.subject.keywordAnhedonia-
dc.subject.keywordEmotional memory-
dc.subject.keywordHippocampus-
dc.subject.keywordNucleus accumbens-
dc.subject.keywordSchizophrenia-
dc.subject.keywordFunctional magnetic resonance imaging (fMRI)-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Jae Jin-
dc.contributor.alternativeNamePark, Hae Jeong-
dc.contributor.alternativeNameLee, Jung Suk-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Jae Jin-
dc.contributor.affiliatedAuthorPark, Hae Jeong-
dc.contributor.affiliatedAuthorLee, Jung Suk-
dc.citation.volume203-
dc.citation.number1-
dc.citation.startPage46-
dc.citation.endPage53-
dc.identifier.bibliographicCitationPSYCHIATRY RESEARCH, Vol.203(1) : 46-53, 2012-
dc.identifier.rimsid31175-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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