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Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author송기준-
dc.contributor.author안상훈-
dc.contributor.author전영은-
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.date.accessioned2014-12-19T17:36:11Z-
dc.date.available2014-12-19T17:36:11Z-
dc.date.issued2012-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91719-
dc.description.abstractBACKGROUND: Transient elastography (TE), a non-invasive tool that measures liver stiffness, has been evaluated in meta-analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC). However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB) is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB. METHODS: Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC) and diagnostic accuracy values of each study. RESULT: A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2), severe fibrosis (F3), and cirrhosis (F4) were 0.859 (95% confidence interval [CI], 0.857-0.860), 0.887 (95% CI, 0.886-0.887), and 0.929 (95% CI, 0.928-0.929), respectively. The estimated cutoff for F2 was 7.9 (range, 6.1-11.8) kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1-9.7) kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3-17.5) kPa, with a sensitivity of 84.6% and specificity of 81.5%. CONCLUSION: TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.-
dc.description.statementOfResponsibilityopen-
dc.format.extente44930-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHArea Under Curve-
dc.subject.MESHElasticity Imaging Techniques/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B virus/physiology-
dc.subject.MESHHepatitis B, Chronic/complications-
dc.subject.MESHHepatitis B, Chronic/diagnosis-
dc.subject.MESHHepatitis B, Chronic/pathology*-
dc.subject.MESHHepatitis B, Chronic/virology-
dc.subject.MESHHumans-
dc.subject.MESHLiver/pathology*-
dc.subject.MESHLiver/virology-
dc.subject.MESHLiver Cirrhosis/complications-
dc.subject.MESHLiver Cirrhosis/diagnosis-
dc.subject.MESHLiver Cirrhosis/pathology*-
dc.subject.MESHLiver Cirrhosis/virology-
dc.subject.MESHMale-
dc.subject.MESHROC Curve-
dc.subject.MESHSeverity of Illness Index-
dc.titlePerformance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biostatistics (의학통계학)-
dc.contributor.googleauthorYoung Eun Chon-
dc.contributor.googleauthorEun Hee Choi-
dc.contributor.googleauthorKi Jun Song-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorSeung Up Kim-
dc.identifier.doi23049764-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA02016-
dc.contributor.localIdA02226-
dc.contributor.localIdA03532-
dc.contributor.localIdA04268-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid23049764-
dc.subject.keywordArea Under Curve-
dc.subject.keywordElasticity Imaging Techniques/methods*-
dc.subject.keywordFemale-
dc.subject.keywordHepatitis B virus/physiology-
dc.subject.keywordHepatitis B, Chronic/complications-
dc.subject.keywordHepatitis B, Chronic/diagnosis-
dc.subject.keywordHepatitis B, Chronic/pathology*-
dc.subject.keywordHepatitis B, Chronic/virology-
dc.subject.keywordHumans-
dc.subject.keywordLiver/pathology*-
dc.subject.keywordLiver/virology-
dc.subject.keywordLiver Cirrhosis/complications-
dc.subject.keywordLiver Cirrhosis/diagnosis-
dc.subject.keywordLiver Cirrhosis/pathology*-
dc.subject.keywordLiver Cirrhosis/virology-
dc.subject.keywordMale-
dc.subject.keywordROC Curve-
dc.subject.keywordSeverity of Illness Index-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameSong, Ki Jun-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameChon, Young Eun-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorSong, Ki Jun-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorChon, Young Eun-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume7-
dc.citation.number9-
dc.citation.startPagee44930-
dc.identifier.bibliographicCitationPLOS ONE, Vol.7(9) : e44930, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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