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Clinical significance of GADD153 expression in stage I non-small cell lung cancer

DC FieldValueLanguage
dc.contributor.author장윤수-
dc.date.accessioned2014-12-19T17:31:59Z-
dc.date.available2014-12-19T17:31:59Z-
dc.date.issued2012-
dc.identifier.issn1792-1074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91585-
dc.description.abstractThe transcription factor growth arrest and DNA damage-inducible gene 153 (GADD153), also known as CHOP, is considered to function as a proapoptotic molecule. Overexpression of GADD153 leads to cell cycle arrest and/or apoptosis. However, its clinical implications in non-small cell lung cancer (NSCLC) remain controversial. Therefore, we investigated the expression of GADD153 in stage I NSCLC using immunohistochemistry. Paraffin-embedded tissue sections from 76 patients, who were diagnosed with primary stage I NSCLC and had undergone a curative lung resection, were stained using an anti-GADD153 antibody. The intensity of GADD153 immunostaining was evaluated within the cell membrane and cytoplasm of invasive cancer components. The correlation between the intratumoral expression of GADD153 and various clinical parameters were explored. GADD153 was detected in 29 (38.2%) cases. No statistically significant difference in expression was demonstrated between stage IA and stage IB tumors (35.0 vs. 39.3%; P=0.735). The expression of GADD153 was not affected by histological subtypes or histological grades of differentiation. The intratumoral expression of GADD153 did not influence the overall survival rate (53.29 vs. 52.18 months; P=0.743) or disease-free survival rate (46.97 vs. 54.19 months; P=0.084) of stage I NSCLC patients. However, patients with GADD153 expression demonstrated an improved disease-specific survival rate (28.80 vs. 53.85 months; P=0.020). No patients with GADD153 expression demonstrated distant metastasis (P=0.029). These data suggest that GADD153 expression may be a valuable prognostic factor of early-stage NSCLC in patients who have undergone curative lung resection.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfOncology Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical significance of GADD153 expression in stage I non-small cell lung cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorCHANG YOUL LEE-
dc.contributor.googleauthorMYUNG GOO LEE-
dc.contributor.googleauthorKYUNG CHAN CHOI-
dc.contributor.googleauthorHEE MO KANG-
dc.contributor.googleauthorYOON SOO CHANG-
dc.identifier.doi10.3892/ol.2012.768-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03456-
dc.relation.journalcodeJ02417-
dc.contributor.alternativeNameChang, Yoon Soo-
dc.contributor.affiliatedAuthorChang, Yoon Soo-
dc.citation.volume4-
dc.citation.number3-
dc.citation.startPage408-
dc.citation.endPage412-
dc.identifier.bibliographicCitationOncology Letters, Vol.4(3) : 408-412, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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