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Visceral fat thickness is associated with carotid atherosclerosis in peritoneal dialysis patients

Authors
 Mi Jung Lee  ;  Dong Ho Shin  ;  Seung Jun Kim  ;  Hyung Jung Oh  ;  Dong Eun Yoo  ;  Jwa-Kyung Kim  ;  Jung Tak Park  ;  Seung Hyeok Han  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Tae-Hyun Yoo 
Citation
 OBESITY, Vol.20(6) : 1301-1307, 2012 
Journal Title
 OBESITY 
ISSN
 1930-7381 
Issue Date
2012
MeSH
Body Mass Index ; C-Reactive Protein/metabolism ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/etiology* ; Carotid Artery Diseases/physiopathology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/pathology* ; Male ; Middle Aged ; Peritoneal Dialysis* ; Risk Factors ; Surveys and Questionnaires ; Waist Circumference*
Keywords
Body Mass Index ; C-Reactive Protein/metabolism ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/etiology* ; Carotid Artery Diseases/physiopathology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Humans ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/pathology* ; Male ; Middle Aged ; Peritoneal Dialysis* ; Risk Factors ; Surveys and Questionnaires ; Waist Circumference*
Abstract
Visceral fat has been known to associate with atherosclerosis, inflammation, and insulin resistance. However, the influence of visceral fat on cardiovascular disease (CVD) in peritoneal dialysis (PD) patients has never been elucidated. We investigated whether visceral fat thickness (VFT) has a predictive role in carotid atherosclerosis determined by carotid intima-media thickness (cIMT) in PD patients. A cross-sectional study was undertaken in 88 prevalent PD patients. BMI and waist circumference (WC) were measured as anthropometric indexes of obesity. VFT and subcutaneous fat thickness (SFT) were determined by sonographic measurement of abdominal fat. Carotid atherosclerosis was defined as increased cIMT (>1.0 mm) or presence of plaque. Thirty-two (36.3%) patients had carotid atherosclerosis. Patients with carotid atherosclerosis showed significantly higher VFT, BMI, and WC. In univariate logistic analysis, BMI, WC, and VFT except SFT were significant risk factors of carotid atherosclerosis. However, multivariate analysis revealed VFT was an independent factor associated with carotid atherosclerosis after adjusting for demographic, biochemical parameters, and anthropometric indexes (per 1 mm increase, odds ratio (OR) = 2.294, 95% confidence interval: 1.048-5.021, P = 0.038). When the patients were divided into three groups according to VFT, log high sensitivity C-reactive protein (hs-CRP), and homeostasis model assessment-insulin resistance (HOMA(IR)) were both higher in the third tertile compared to other tertiles. In conclusion, VFT, not SFT, is independently associated with carotid atherosclerosis in PD patients. Therefore sonographic measurement of VFT could be useful to stratify the risk of cardiovascular disease in PD patients.
Full Text
http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.245/abstract
DOI
21818151
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Seung Jun(김승준)
Kim, Jwa Kyung(김좌경)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Oh, Hyung Jung(오형중)
Yoo, Dong Eun(유동은)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91580
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