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Prediction of outcomes for patients with brain parenchymal metastases from breast cancer (BC): a new BC-specific prognostic model and a nomogram

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dc.contributor.author손주혁-
dc.contributor.author이수현-
dc.date.accessioned2014-12-19T17:30:23Z-
dc.date.available2014-12-19T17:30:23Z-
dc.date.issued2012-
dc.identifier.issn1522-8517-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91535-
dc.description.abstractThe purpose of this study is to validate the recently published Breast-Graded Prognostic Assessment (GPA) and propose a new prognostic model and nomogram for patients with brain parenchymal metastases (BM) from breast cancer (BC). We retrospectively investigated 171 consecutive patients who received a diagnosis of BM from BC during 2000-2008. We appraised the recently proposed Sperduto's BC-specific GPA in training cohort through Kaplan-Meier survival curve using log-rank test and area under the curve for the BC-GPA predicting overall survival at 1 year and developed a new nomogram to predict outcomes using multivariate Cox-regression analysis. By putting the Sperduto's Breast-GPA together with our nomogram, we developed a new prognostic model. We validated our new prognostic model with an independent external patient cohort from 2 institutes for the same period. On the basis of our Cox-regression analysis, therapeutic effect of trastuzumab and status of extracranial systemic disease control were incorporated into our new prognostic model in addition to Karnofsky performance status, age, and hormonal status. Our new prognostic model showed significant discrimination in median survival time, with 3.7 months for class I (n = 15), 7.8 months for class II (n = 82), 10.7 months for class III (n = 42), and 19.2 months for class IV (n = 32; P < .0001). The new prognostic model accurately predicted survival among patients with BC from BM in an external validation cohort (P < .0001). We propose a new prognostic model and a nomogram reflecting the different biological features of BC, including treatment effect and status of extracranial disease control, which was excellently validated in an independent external cohort.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNEURO-ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/mortality*-
dc.subject.MESHAdenocarcinoma/secondary-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHArea Under Curve-
dc.subject.MESHBrain Neoplasms/mortality*-
dc.subject.MESHBrain Neoplasms/secondary-
dc.subject.MESHBreast Neoplasms/mortality*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNomograms*-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHROC Curve-
dc.subject.MESHTreatment Outcome-
dc.titlePrediction of outcomes for patients with brain parenchymal metastases from breast cancer (BC): a new BC-specific prognostic model and a nomogram-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHee Kyung Ahn-
dc.contributor.googleauthorSoohyeon Lee-
dc.contributor.googleauthorYeon Hee Park-
dc.contributor.googleauthorJoo Hyuk Sohn-
dc.contributor.googleauthorJae-Cheol Jo-
dc.contributor.googleauthorJin-Hee Ahn-
dc.contributor.googleauthorKyung Hae Jung-
dc.contributor.googleauthorSilvia Park-
dc.contributor.googleauthorEun Yoon Cho-
dc.contributor.googleauthorJung Il Lee-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorDoo Ho Choi-
dc.contributor.googleauthorSeung Jae Huh-
dc.contributor.googleauthorJin Seok Ahn-
dc.contributor.googleauthorSung-Bae Kim-
dc.contributor.googleauthorYoung-Hyuck Im-
dc.identifier.doi22693244-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01995-
dc.contributor.localIdA02898-
dc.relation.journalcodeJ02346-
dc.identifier.eissn1523-5866-
dc.identifier.pmid22693244-
dc.subject.keywordAdenocarcinoma/mortality*-
dc.subject.keywordAdenocarcinoma/secondary-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAged, 80 and over-
dc.subject.keywordArea Under Curve-
dc.subject.keywordBrain Neoplasms/mortality*-
dc.subject.keywordBrain Neoplasms/secondary-
dc.subject.keywordBreast Neoplasms/mortality*-
dc.subject.keywordBreast Neoplasms/pathology-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordKaplan-Meier Estimate-
dc.subject.keywordMiddle Aged-
dc.subject.keywordNomograms*-
dc.subject.keywordPrognosis-
dc.subject.keywordProportional Hazards Models-
dc.subject.keywordROC Curve-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNameSohn, Joo Hyuk-
dc.contributor.alternativeNameLee, Soo Hyeon-
dc.contributor.affiliatedAuthorSohn, Joo Hyuk-
dc.contributor.affiliatedAuthorLee, Soo Hyeon-
dc.citation.volume14-
dc.citation.number8-
dc.citation.startPage1105-
dc.citation.endPage1113-
dc.identifier.bibliographicCitationNEURO-ONCOLOGY, Vol.14(8) : 1105-1113, 2012-
dc.identifier.rimsid29286-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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