108 132

Cited 0 times in

Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair

Authors
 Jung, Hosung  ;  Yoon, Byung  ;  Holt, Christine 
Citation
 Nature Reviews. Neuroscience, Vol.13(5) : 308-324, 2012 
Journal Title
 Nature Reviews. Neuroscience 
ISSN
 1471-003X 
Issue Date
2012
Abstract
mRNAs can be targeted to specific neuronal subcellular domains, which enables rapid changes in the local proteome through local translation. This mRNA-based mechanism links extrinsic signals to spatially restricted cellular responses and can mediate stimulus-driven adaptive responses such as dendritic plasticity. Local mRNA translation also occurs in growing axons where it can mediate directional responses to guidance signals. Recent profiling studies have revealed that both growing and mature axons possess surprisingly complex and dynamic transcriptomes, thereby suggesting that axonal mRNA localization is highly regulated and has a role in a broad range of processes, a view that is increasingly being supported by new experimental evidence. Here, we review current knowledge on the roles and regulatory mechanisms of axonal mRNA translation and discuss emerging links to axon guidance, survival, regeneration and neurological disorders.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91508
DOI
10.1038/nrn3210.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실)
Yonsei Authors
정호성(Jung, Ho Sung)
사서에게 알리기
  feedback
Files in This Item:
T201205531.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse