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Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

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dc.contributor.author라선영-
dc.date.accessioned2014-12-19T17:29:21Z-
dc.date.available2014-12-19T17:29:21Z-
dc.date.issued2012-
dc.identifier.issn1061-4036-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91503-
dc.description.abstractGastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas and their matched normal DNAs. Frequently mutated genes in the adenocarcinomas included TP53 (11/15 tumors), PIK3CA (3/15) and ARID1A (3/15). Cell adhesion was the most enriched biological pathway among the frequently mutated genes. A prevalence screening confirmed mutations in FAT4, a cadherin family gene, in 5% of gastric cancers (6/110) and FAT4 genomic deletions in 4% (3/83) of gastric tumors. Frequent mutations in chromatin remodeling genes (ARID1A, MLL3 and MLL) also occurred in 47% of the gastric cancers. We detected ARID1A mutations in 8% of tumors (9/110), which were associated with concurrent PIK3CA mutations and microsatellite instability. In functional assays, we observed both FAT4 and ARID1A to exert tumor-suppressor activity. Somatic inactivation of FAT4 and ARID1A may thus be key tumorigenic events in a subset of gastric cancers.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNATURE GENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCell Adhesion/genetics*-
dc.subject.MESHChromatin Assembly and Disassembly/genetics*-
dc.subject.MESHDNA/genetics-
dc.subject.MESHExome/genetics*-
dc.subject.MESHGenes, Tumor Suppressor*-
dc.subject.MESHHumans-
dc.subject.MESHMicrosatellite Instability-
dc.subject.MESHMutation/genetics*-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHPolymorphism, Single Nucleotide/genetics-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHStomach/metabolism-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.titleExome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorZhi Jiang Zang-
dc.contributor.googleauthorIoana Cutcutache-
dc.contributor.googleauthorSong Ling Poon-
dc.contributor.googleauthorShen Li Zhang-
dc.contributor.googleauthorJohn R McPherson-
dc.contributor.googleauthorJiong Tao-
dc.contributor.googleauthorVikneswari Rajasegaran-
dc.contributor.googleauthorHong Lee Heng-
dc.contributor.googleauthorNiantao Deng-
dc.contributor.googleauthorAnna Gan-
dc.contributor.googleauthorKiat Hon Lim-
dc.contributor.googleauthorChoon Kiat Ong-
dc.contributor.googleauthorDaChuan Huang-
dc.contributor.googleauthorSze Yung Chin-
dc.contributor.googleauthorIain Beehuat Tan-
dc.contributor.googleauthorCedric Chuan Young Ng-
dc.contributor.googleauthorWillie Yu-
dc.contributor.googleauthorYingting Wu-
dc.contributor.googleauthorMinghui Lee-
dc.contributor.googleauthorJeanie Wu-
dc.contributor.googleauthorDianne Poh-
dc.contributor.googleauthorWei Keat Wan-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorJimmy So-
dc.contributor.googleauthorManuel Salto-Tellez-
dc.contributor.googleauthorKhay Guan Yeoh-
dc.contributor.googleauthorWai Keong Wong-
dc.contributor.googleauthorYi-Jun Zhu-
dc.contributor.googleauthorP Andrew Futreal-
dc.contributor.googleauthorBrendan Pang-
dc.contributor.googleauthorYijun Ruan-
dc.contributor.googleauthorAxel M Hillmer-
dc.contributor.googleauthorDenis Bertrand-
dc.contributor.googleauthorNiranjan Nagarajan-
dc.contributor.googleauthorSteve Rozen-
dc.contributor.googleauthorBin Tean Teh-
dc.contributor.googleauthorPatrick Tan-
dc.identifier.doi22484628-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ02294-
dc.identifier.eissn1546-1718-
dc.identifier.pmid22484628-
dc.identifier.urlhttp://www.nature.com/ng/journal/v44/n5/full/ng.2246.html-
dc.subject.keywordAdenocarcinoma/genetics*-
dc.subject.keywordCase-Control Studies-
dc.subject.keywordCell Adhesion/genetics*-
dc.subject.keywordChromatin Assembly and Disassembly/genetics*-
dc.subject.keywordDNA/genetics-
dc.subject.keywordExome/genetics*-
dc.subject.keywordGenes, Tumor Suppressor*-
dc.subject.keywordHumans-
dc.subject.keywordMicrosatellite Instability-
dc.subject.keywordMutation/genetics*-
dc.subject.keywordPolymerase Chain Reaction-
dc.subject.keywordPolymorphism, Single Nucleotide/genetics-
dc.subject.keywordSequence Analysis, DNA-
dc.subject.keywordStomach/metabolism-
dc.subject.keywordStomach Neoplasms/genetics*-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.citation.volume44-
dc.citation.number5-
dc.citation.startPage570-
dc.citation.endPage574-
dc.identifier.bibliographicCitationNATURE GENETICS, Vol.44(5) : 570-574, 2012-
dc.identifier.rimsid31317-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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