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Mass-producible nano-featured polystyrene surfaces for regulating the differentiation of human adipose-derived stem cells.

Authors
 Kwang-Sook Park  ;  Kyoung Je Cha  ;  In-Bo Han  ;  Dong-Ah Shin  ;  Dong-Woo Cho  ;  Soo-Hong Lee  ;  Dong Sung Kim 
Citation
 Macromolecular Bioscience, Vol.12(11) : 1480-1489, 2012 
Journal Title
 Macromolecular Bioscience 
ISSN
 1616-5187 
Issue Date
2012
Abstract
In this study, we report an efficient and cost-effective method of fabricating polystyrene (PS) nano-featured substrates containing nanopore (NPo) and nanopillar (NPi) arrays based on hot embossing using nickel nano-stamps. We investigate the behavior of adipose-derived stem cells (ASCs), including adhesion, morphology, proliferation and differentiation, on the replicated PS surfaces. Compared to a flat substrate, NPo- and NPi-featured substrates do not alter the morphology of stem cells. However, both NPo- and NPi-featured substrates induce different integrin expression and lower formation of focal adhesion complexes. In addition, ASCs on the NPo-featured substrate exhibit greater adipogenic differentiation, while the NPi-featured substrate induces higher osteogenic differentiation.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91427
DOI
10.1002/mabi.201200225
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
신동아(Shin, Dong A)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200225/abstract
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