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Mass-producible nano-featured polystyrene surfaces for regulating the differentiation of human adipose-derived stem cells.

Authors
 Kwang-Sook Park  ;  Kyoung Je Cha  ;  In-Bo Han  ;  Dong-Ah Shin  ;  Dong-Woo Cho  ;  Soo-Hong Lee  ;  Dong Sung Kim 
Citation
 MACROMOLECULAR BIOSCIENCE, Vol.12(11) : 1480-1489, 2012 
Journal Title
 MACROMOLECULAR BIOSCIENCE 
ISSN
 1616-5187 
Issue Date
2012
MeSH
Adipocytes/cytology ; Adipocytes/drug effects* ; Biocompatible Materials/chemical synthesis* ; Biocompatible Materials/pharmacology ; Cell Adhesion/drug effects ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Chondrogenesis/drug effects ; Gene Expression ; Humans ; Integrins/genetics ; Integrins/metabolism ; Microscopy, Electron, Scanning ; Nanostructures/chemistry* ; Nanostructures/ultrastructure ; Nickel/chemistry ; Osteogenesis/drug effects ; Polystyrenes/chemistry* ; Stem Cells/cytology ; Stem Cells/drug effects* ; Surface Properties
Keywords
Adipocytes/cytology ; Adipocytes/drug effects* ; Biocompatible Materials/chemical synthesis* ; Biocompatible Materials/pharmacology ; Cell Adhesion/drug effects ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Chondrogenesis/drug effects ; Gene Expression ; Humans ; Integrins/genetics ; Integrins/metabolism ; Microscopy, Electron, Scanning ; Nanostructures/chemistry* ; Nanostructures/ultrastructure ; Nickel/chemistry ; Osteogenesis/drug effects ; Polystyrenes/chemistry* ; Stem Cells/cytology ; Stem Cells/drug effects* ; Surface Properties
Abstract
In this study, we report an efficient and cost-effective method of fabricating polystyrene (PS) nano-featured substrates containing nanopore (NPo) and nanopillar (NPi) arrays based on hot embossing using nickel nano-stamps. We investigate the behavior of adipose-derived stem cells (ASCs), including adhesion, morphology, proliferation and differentiation, on the replicated PS surfaces. Compared to a flat substrate, NPo- and NPi-featured substrates do not alter the morphology of stem cells. However, both NPo- and NPi-featured substrates induce different integrin expression and lower formation of focal adhesion complexes. In addition, ASCs on the NPo-featured substrate exhibit greater adipogenic differentiation, while the NPi-featured substrate induces higher osteogenic differentiation.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200225/abstract
DOI
23042782
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Ah(신동아) ORCID logo https://orcid.org/0000-0002-5225-4083
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91427
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