Cited 6 times in
Lamivudine plus adefovir vs. entecavir in HBeAg-positive hepatitis B with sequential treatment failure of lamivudine and adefovir
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도영 | - |
dc.contributor.author | 류한작 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 손창영 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이명하 | - |
dc.contributor.author | 이중민 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2014-12-19T17:26:32Z | - |
dc.date.available | 2014-12-19T17:26:32Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91415 | - |
dc.description.abstract | BACKGROUND AND AIMS: Few studies have adequately examined the efficacy of lamivudine plus adefovir (LAM+ADV) combination therapy vs. entecavir (ETV) monotherapy in HBeAg-positive hepatitis B patients who fail to respond to sequential treatment with LAM and ADV. We compared directly the efficacy of LAM+ADV vs. ETV in such patients and assessed prognostic factors associated with a virologic response at month 12. METHODS: In total, 72 HBeAg-positive patients who showed resistance (n = 33) or a suboptimal virologic response (n = 39) to ADV monotherapy with resistance to LAM therapy underwent rescue therapy (31 LAM+ADV and 41 ETV). All patients were followed for at least 12 months. RESULTS: Following 12 months of treatment, in the LAM+ADV and ETV groups, a virologic response was observed in 7/31 (22.6%) and 8/41 (19.5%; P = 0.777) patients; ALT normalization occurred in 11/13 (84.6%) and 16/18 (88.9%; P = 0.566); HBeAg seroconversion in 1/31 (2.3%) and 4/41 (9.8%; P = 0.341) and a virologic breakthrough in 3/31 (9.0%) and 5/41 (12.1%; P = 0.452) respectively. Independent prognostic factors associated with a virologic response were the baseline HBV-DNA level (OR = 0.37; 95% CI 0.17-0.80; P = 0.011) and the duration of prior ADV monotherapy (OR = 0.89; 95% CI 0.83-0.95; P = 0.044). CONCLUSIONS: Neither LAM+ADV nor ETV was adequately effective in patients with sequential LAM and ADV treatment failure. Thus, when chronic hepatitis B patients show resistance or suboptimal response to ADV monotherapy, early modification of treatment should be considered. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenine/analogs & derivatives* | - |
dc.subject.MESH | Adenine/therapeutic use | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alanine Transaminase/blood | - |
dc.subject.MESH | Antiviral Agents/therapeutic use* | - |
dc.subject.MESH | DNA, Viral/blood | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Guanine/analogs & derivatives* | - |
dc.subject.MESH | Guanine/therapeutic use | - |
dc.subject.MESH | Hepatitis B/drug therapy* | - |
dc.subject.MESH | Hepatitis B e Antigens/analysis | - |
dc.subject.MESH | Hepatitis B e Antigens/metabolism* | - |
dc.subject.MESH | Hepatitis B, Chronic/drug therapy | - |
dc.subject.MESH | Hepatitis B, Chronic/virology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lamivudine/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Organophosphonates/therapeutic use* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Failure | - |
dc.title | Lamivudine plus adefovir vs. entecavir in HBeAg-positive hepatitis B with sequential treatment failure of lamivudine and adefovir | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Chang Young Son | - |
dc.contributor.googleauthor | Han Jak Ryu | - |
dc.contributor.googleauthor | Jung Min Lee | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Myoung Ha Lee | - |
dc.contributor.googleauthor | Kwang Hyub Han | - |
dc.contributor.googleauthor | Chae Yoon Chon | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.identifier.doi | 10.1111/j.1478-3231.2012.02793.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01334 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A01997 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02758 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A03184 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 22452737 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2012.02793.x/abstract | - |
dc.subject.keyword | adefovir | - |
dc.subject.keyword | entecavir | - |
dc.subject.keyword | (HBeAg-positive)chronic hepatitis B | - |
dc.subject.keyword | lamivudine | - |
dc.subject.keyword | sequentialtherapy | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Ryu, Han Jak | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Son, Chang Young | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Myoung Ha | - |
dc.contributor.alternativeName | Lee, Jung Min | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Ryu, Han Jak | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Son, Chang Young | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Myoung Ha | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Lee, Jung Min | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 32 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1179 | - |
dc.citation.endPage | 1185 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.32(7) : 1179-1185, 2012 | - |
dc.identifier.rimsid | 31264 | - |
dc.type.rims | ART | - |
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