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Non-bacterial infections in Asian patients treated with alemtuzumab:a retrospective study of the Asian Lymphoma Study Group

DC FieldValueLanguage
dc.contributor.author김진석-
dc.date.accessioned2014-12-19T17:25:50Z-
dc.date.available2014-12-19T17:25:50Z-
dc.date.issued2012-
dc.identifier.issn1042-8194-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91393-
dc.description.abstractThis retrospective study concerns non-bacterial infections in Asian patients receiving alemtuzumab. The clinical data of 182 patients treated with alemtuzumab alone or alemtuzumab-containing chemotherapy between the years 2003 and 2009 was collected from six Asian countries. Alemtuzumab was used in the setting of frontline (n =48) or salvage (n =90) treatment, and as a part of the conditioning regimen for allogeneic stem cell transplant (n =44). Reactivation of cytomegalovirus (66/182) and varicella zoster virus (25/182), and fungal infection (31/182) including invasive pulmonary aspergillosis, were the most common infectious complications in this retrospective analysis. Thus, we recommend routine prophylaxis with valganciclovir and itraconazole, especially when alemtuzumab is used in the conditioning regimen for allogeneic stem cell transplant. Pneumocystis jirovecii pneumonia (PJP) was found in four patients (3%, 4/122) receiving alemtuzumab as conditioning for stem cell transplant or salvage treatment. Three cases of hepatitis B virus reactivation were found in antigen-negative patients, and 16 cases of tuberculosis were observed. Infection is the major complication of alemtuzumab therapy, and these infectious complications are potentially severe and life-threatening. Based on our retrospective analysis, we have constructed a guideline for antimicrobial prophylaxis in Asian patients receiving alemtuzumab therapy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfLEUKEMIA & LYMPHOMA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlemtuzumab-
dc.subject.MESHAntibodies, Monoclonal, Humanized/adverse effects*-
dc.subject.MESHAntineoplastic Agents/adverse effects-
dc.subject.MESHAsia-
dc.subject.MESHChild-
dc.subject.MESHCytomegalovirus Infections/complications-
dc.subject.MESHFemale-
dc.subject.MESHHerpes Zoster/complications-
dc.subject.MESHHumans-
dc.subject.MESHLymphoma/complications-
dc.subject.MESHLymphoma/drug therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMycoses/complications-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSalvage Therapy/methods-
dc.subject.MESHStem Cell Transplantation/methods-
dc.subject.MESHTransplantation Conditioning/methods-
dc.subject.MESHTransplantation, Homologous/methods-
dc.titleNon-bacterial infections in Asian patients treated with alemtuzumab:a retrospective study of the Asian Lymphoma Study Group-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeok Jin Kim-
dc.contributor.googleauthorJoon Ho Moon-
dc.contributor.googleauthorHawk Kim-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorYu Yan Hwang-
dc.contributor.googleauthorTanin Intragumtornchai-
dc.contributor.googleauthorSurapol Issaragrisil-
dc.contributor.googleauthorJae Yong Kwak-
dc.contributor.googleauthorJe Jung Lee-
dc.contributor.googleauthorJong Ho Won-
dc.contributor.googleauthorArry Harryanto Reksodiputro-
dc.contributor.googleauthorSoon Thye Lim-
dc.contributor.googleauthorAnn-Lii Cheng-
dc.contributor.googleauthorWon Seog Kim-
dc.contributor.googleauthorYok Lam Kwong-
dc.identifier.doi22273250-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01017-
dc.relation.journalcodeJ02165-
dc.identifier.eissn1029-2403-
dc.identifier.pmid22273250-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.3109/10428194.2012.659735-
dc.subject.keywordAlemtuzumab-
dc.subject.keywordinfection-
dc.subject.keywordprophylaxis-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.citation.volume53-
dc.citation.number8-
dc.citation.startPage1515-
dc.citation.endPage1524-
dc.identifier.bibliographicCitationLEUKEMIA & LYMPHOMA, Vol.53(8) : 1515-1524, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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