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Cytologic features of giant cell ependymoma: a case report and review of the literature.

Authors
 Myoung Ju Koh  ;  Sun Och Yoon  ;  Hyae Min Jeon  ;  Hyeon Joo Jeong  ;  Soon Won Hong  ;  Se Hoon Kim 
Citation
 Korean Journal of Pathology, Vol.46(5) : 507-513, 2012 
Journal Title
 Korean Journal of Pathology 
ISSN
 1738-1843 
Issue Date
2012
Abstract
Here, we present a case of anaplastic giant cell ependymoma (GCE) occurring in a 15-year-old woman. Squash smear slides for intraoperative frozen section diagnosis revealed oval to round cell clusters with a papillary structure in a fibrillary background. This was occasionally accompanied by the presence of bizarre pleomorphic giant cells with hyperchromatic nuclei and prominent intranuclear inclusions. These intranuclear inclusions were a key clue to diagnosis of ependymoma. Histologic analysis revealed features of a high-grade tumor with perivascular pseudorosettes and bizarre pleomorphic giant cells, which established the diagnosis of GCE. We performed a review of literatures about the cytologic features of GCE, including our case, thus proposing that intraoperative frozen diagnosis of GCE would be established by squash smear preparations featuring the mitosis and necrosis, as well as the high cellularity, and the presence of giant cells showing hyperchromatic nuclei with eosinophilic cytoplasm and intranuclear inclusions/pseudoinclusions.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91313
DOI
10.4132/KoreanJPathol.2012.46.5.507
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김세훈(Kim, Se Hoon)
윤선옥(Yoon, Sun Och)
정현주(Jeong, Hyeon Joo)
홍순원(Hong, Soon Won)
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