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Difference in serum nephrin expression between normal and preeclamptic pregnancies: A preliminary study.

Other Titles
 정상 산모들과 임신중독증 산모들의 혈청 중 네프린 발현 빈도의 차이: 예비결과 보고 
 Bit Na Rae Kim  ;  Ja Young Kwon  ;  Yejin Park  ;  Myung Hwa Kang  ;  Jong Rak Choi  ;  Young Geun Kwon  ;  Young Han Kim  ;  Yong Won Park 
 Korean Journal of Obstetrics and Gynecology, Vol.55(8) : 546-551, 2012 
Journal Title
Korean Journal of Obstetrics and Gynecology
Issue Date
Preeclampsia ; Nephrin ; Serum
OBJECTIVE: Nephrin is one of the slit membrane proteins of podocytes in the kidney. It is known that the nephrin is shed in the urine in nephropathy accompanying proteinuira. So the aim of this study was to evaluate the difference in the serum nephrin expression between normal and preeclamptic pregnancies. METHODS: A total of 20 pregnant women from May to September 2008 who received prenatal care and underwent delivery at our institute participated in the study. The preeclamptic group includes 13 women diagnosed as preeclampsia and a normal group of 7. Their serum were collected before delivery and analyzed by Western blotting for comparing serum nephrin expression. RESULTS: There was no difference in age, body weight of pregnant women, blood urea nitrogen, serum creatinine, urine creatinine level and gestational age between two groups. However, preeclampsia group had significantly higher systolic and diastolic blood pressure (P<0.001), serum soluble fms-like tyrosine kinase-1 level (P=0.002), and lower birth weight (P=0.011). In serum Western blot analysis, serum nephrin was detected in 10 of 13 in preeclampsia women (76.9%) but only in 2 of 7 (28.6%) in normal pregnancy women showing statistically significant difference (P=0.032). CONCLUSION: A higher prevalence of nephrin expression in the maternal serum was found in the preeclampsia when compared to the normal pregnancy.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Myung Hwa(강명화)
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
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