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Effects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass.

DC FieldValueLanguage
dc.contributor.author곽영란-
dc.contributor.author오세영-
dc.contributor.author이우경-
dc.contributor.author최용선-
dc.date.accessioned2014-12-19T17:20:32Z-
dc.date.available2014-12-19T17:20:32Z-
dc.date.issued2012-
dc.identifier.issn2005-6419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91230-
dc.description.abstractBACKGROUND: We determined the protective effects of a high dose of ulinastatin on myocardial and renal function in patients undergoing aortic valve replacement with cardiopulmonary bypass (CPB). METHODS: Sixty patients were assigned randomly to either the ulinastatin group (n = 30) or the control group (n = 30). In the ulinastatin group, ulinastatin (300,000 U) was given after the induction of anesthesia, ulinastatin (400,000 U) was added to the CPB pump prime, and then ulinastatin (300,000 U) was administered after weaning from CPB. In the control group, the same volume of saline was administered at the same time points. Creatine kinase-MB levels were assessed 1 day before surgery, and on the first and second postoperative day (POD 1 and 2). Serum creatinine and cystatin C levels were assessed 1 day before surgery, upon intensive care unit arrival, and on POD 1 and 2. The level of plasma neutrophil gelatinase-associated lipocalin was assessed before induction of anesthesia, upon ICU arrival, and on POD 1. RESULTS: No significant differences were observed in serum levels of creatine kinase-MB and biomarkers of renal injury between the two groups at any point during the study period. CONCLUSIONS: Ulinastatin showed no cardiac or renal protective effects after CPB in patients undergoing aortic valve replacement.-
dc.description.statementOfResponsibilityopen-
dc.format.extent148~153-
dc.relation.isPartOfKorean Journal of Anesthesiology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSe-young Oh-
dc.contributor.googleauthorJong Chan Kim-
dc.contributor.googleauthorYong Seon Choi-
dc.contributor.googleauthorWoo Kyung Lee-
dc.contributor.googleauthorYeong-Kyu Lee-
dc.contributor.googleauthorYoung Lan Kwak-
dc.identifier.doi22379570-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00172-
dc.contributor.localIdA02377-
dc.contributor.localIdA04119-
dc.contributor.localIdA02990-
dc.relation.journalcodeJ01963-
dc.identifier.pmid22379570-
dc.subject.keywordCardiac surgical procedures-
dc.subject.keywordCardiopulmonary bypass-
dc.subject.keywordMyocardiac protection-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameOh, Se Young-
dc.contributor.alternativeNameLee, Woo Kyung-
dc.contributor.alternativeNameChoi, Yong Seon-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorOh, Se Young-
dc.contributor.affiliatedAuthorChoi, Yong Seon-
dc.contributor.affiliatedAuthorLee, Woo Kyung-
dc.citation.volume62-
dc.citation.number2-
dc.citation.startPage148-
dc.citation.endPage153-
dc.identifier.bibliographicCitationKorean Journal of Anesthesiology, Vol.62(2) : 148-153, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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