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Resolution of type 2 diabetes after gastrectomy for gastric cancer with long limb Roux-en Y reconstruction: a prospective pilot study

DC Field Value Language
dc.contributor.author김종원-
dc.contributor.author안철우-
dc.contributor.author최승호-
dc.date.accessioned2014-12-19T17:18:20Z-
dc.date.available2014-12-19T17:18:20Z-
dc.date.issued2013-
dc.identifier.issn2233-7903-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91163-
dc.description.abstractPURPOSE: It is unclear whether metabolic surgery is effective in non obese type 2 diabetes mellitus (T2DM) and the result after gastrectomy and conventional reconstruction for gastric cancer with non obese T2DM are not satisfactory for improvement of T2DM. Prospective single-arm pilot study with long limb Roux-en Y reconstruction after gastrectomy was evaluated on its safety and efficacy as a potential cure for T2DM in patients with non obese gastric cancer. METHODS: Fifteen patients with non obese T2DM and gastric cancer were enrolled. After gastrectomy, the gastrointestinal tract was reconstructed by Roux-en Y gastrojejunostomy or esophagojejunostomy. The biliopancreatic and Roux limb were 100 to 120 cm long each. RESULTS: There was no surgery-related mortality, but four cases experienced complications (26.7%). Before surgery, the mean body mass index was 25.2 ± 3.4 kg/m(2) and mean glycated hemoglobin (HbA1c) was 7.7 ± 1.4% with antidiabetic medications. The mean BMI decreased to 21.7 ± 3.1 kg/m(2) (P < 0.05) and the mean HbA1c decreased to 6.3 ± 0.8% (P < 0.05) 6 months after surgery. At the end of the study (follow-up duration, 12.5 ± 5.5 months), HbA1c decreased to <6% in 11 patients (78.6%) without any antidiabetic medications. There were no patients who had anemia, and/or malnutrition after surgery except one patient who died due to recurrence four months after surgery. CONCLUSION: Long limb Roux-en Y reconstruction after gastrectomy is feasible and has the potential to cure T2DM in non obese gastric cancer patients. A randomized controlled trial is needed to confirm this result.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF THE KOREAN SURGICAL SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleResolution of type 2 diabetes after gastrectomy for gastric cancer with long limb Roux-en Y reconstruction: a prospective pilot study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorWhan Sik Kim-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorSeung Ho Choi-
dc.identifier.doi10.4174/jkss.2013.84.2.88-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02270-
dc.contributor.localIdA04102-
dc.contributor.localIdA00925-
dc.relation.journalcodeJ01892-
dc.identifier.eissn2093-0488-
dc.identifier.pmid23396643-
dc.subject.keywordGastrectomy-
dc.subject.keywordRoux-en-Y anastomosis-
dc.subject.keywordStomach neoplasms-
dc.subject.keywordType 2 diabetes mellitus-
dc.contributor.alternativeNameKim, Jong Won-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Jong Won-
dc.citation.volume84-
dc.citation.number2-
dc.citation.startPage88-
dc.citation.endPage93-
dc.identifier.bibliographicCitationJOURNAL OF THE KOREAN SURGICAL SOCIETY , Vol.84(2) : 88-93, 2013-
dc.identifier.rimsid33957-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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